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Federal
Clinical review: Intensive care follow-up – what has it told us?
U.S. Department of Health & Human Services —
The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty... -
Federal
Expression profiling of
U.S. Department of Health & Human Services —
A combination of linear RNA amplification and DNA microarray hybridization has allowed the determination of expression profiles of individual imaginal discs and... -
Federal
Prevalence of hepatitis B and C markers in high-risk hospitalised patients in Crete: a five-year observational study
U.S. Department of Health & Human Services —
Background So far the prevalence of viral hepatitis infection in hospitalized patients has not been extensively studied. Therefore we conducted the present five-year... -
Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this... -
Federal
Evolutionary conservation of
U.S. Department of Health & Human Services —
Background Homeobox genes of the orthodenticle (otd)/Otx family have conserved roles in the embryogenesis of head and brain. Gene replacement experiments show that... -
Federal
On the species of origin: diagnosing the source of symbiotic transcripts
U.S. Department of Health & Human Services —
Background Most organisms have developed ways to recognize and interact with other species. Symbiotic interactions range from pathogenic to mutualistic. Some... -
Federal
Gene expression neighborhoods
U.S. Department of Health & Human Services —
The finding that neighboring eukaryotic genes are often expressed in similar patterns suggests the involvement of chromatin domains in the control of genes within a... -
Federal
Detection ofMycobacterium avium subspecies paratuberculosisspecific IS900 insertion sequences in bulk-tank milk samples obtained from different regions throughout Switzerland
U.S. Department of Health & Human Services —
SinceMycobacterium aviumsubspeciesparatuberculosis(MAP) was isolated from intestinal tissue of a human patient suffering Crohn's disease, a controversial discussion... -
Federal
The MRC trial of assessment and management of older people in the community: objectives, design and interventions [ISRCTN23494848]
U.S. Department of Health & Human Services —
Background The benefit of regular multidimensional assessment of older people remains controversial. The majority of trials have been too small to produce adequate... -
Federal
Rhythmic expression of
U.S. Department of Health & Human Services —
Background Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the... -
Federal
Evolution and phylogeny of insect endogenous retroviruses
U.S. Department of Health & Human Services —
Background The genome of invertebrates is rich in retroelements which are structurally reminiscent of the retroviruses of vertebrates. Those containing three open... -
Federal
Beta-Adrenergic gene therapy for cardiovascular disease
U.S. Department of Health & Human Services —
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for... -
Federal
"In-gel" purified ditags direct synthesis of highly efficient SAGE Libraries
U.S. Department of Health & Human Services —
Background SAGE (serial analysis of gene expression) is a recently developed technique for systematic analysis of eukaryotic transcriptomes. The most critical step in... -
Federal
Identification of two
U.S. Department of Health & Human Services —
Background The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause... -
Federal
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
U.S. Department of Health & Human Services —
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult,... -
Federal
TheTnfrh1(Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
U.S. Department of Health & Human Services —
TheTnfrh1gene (gene symbolTnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest... -
Federal
TheG-308Avariant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution
U.S. Department of Health & Human Services —
Tumor Necrosis Factor-α (TNF-α) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-α in adipose tissue has... -
Federal
Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (
U.S. Department of Health & Human Services —
Background: Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that... -
Federal
The role of soil factors and leaf protein in the utilization of mopane plants by elephants in northern Botswana
U.S. Department of Health & Human Services —
Background Mopane (Colophospermum mopane) plants form monotypic woodlands that cover extensive areas in northern Botswana. Mopane is also a principal food item in the... -
Federal
Efficacy ofHelicobacter pylorieradication therapies: a single centre observational study
U.S. Department of Health & Human Services —
ManyHelicobacter pylorieradication regimens have been described. There are little data reporting their efficacy or integration in routine clinical practice. The...