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Federal
Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes
U.S. Department of Health & Human Services —
Background Thyroid hormones are well known modulators of signal transduction. The effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase C (DAG/PKC)... -
Federal
Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
U.S. Department of Health & Human Services —
Background During the last decade, medium-dose UVA1 phototherapy (50 J/cm2) has achieved great value within the treatment of severe atopic dermatitis (AD). The... -
Federal
Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
U.S. Department of Health & Human Services —
Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial... -
Federal
Subunit modification and association in VR1 ion channels
U.S. Department of Health & Human Services —
Background The capsaicin (vanilloid) receptor, VR1, is an agonist-activated ion channel expressed by sensory neurons that serves as a detector of chemical and thermal... -
Federal
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line
U.S. Department of Health & Human Services —
Background Tetracycline-regulated systems have been used to control the expression of heterologous genes in such diverse organisms as yeast, plants, flies and mice.... -
Federal
Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis
U.S. Department of Health & Human Services —
Nidovirus subgenomic mRNAs contain a leader sequence derived from the 5′ end of the genome fused to different sequences (‘bodies’) derived from the 3′ end. Their... -
Federal
Blood borne transit of CJD from brain to gut at early stages of infection
U.S. Department of Health & Human Services —
Background In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which... -
Federal
Rational use of computerized protocols in the intensive care unit
U.S. Department of Health & Human Services —
Excess information in complex ICU environments exceeds human decision making limits, increasing the likelihood of clinical errors. Explicit decision-support tools... -
Federal
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
U.S. Department of Health & Human Services —
Background The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible... -
Federal
Treatment of achalasia: the short-term response to botulinum toxin injection seems to be independent of any kind of pretreatment
U.S. Department of Health & Human Services —
Background It has been suggested that intrasphincteric injection of botulinum toxin (BTX) may represent an alternative therapy to balloon dilatation in achalasia. The... -
Federal
Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.
U.S. Department of Health & Human Services —
Background The role of glucokinase (GCK) in the pathogenesis of maturity-onset diabetes of the young is well established. However, its role in the common form of type... -
Federal
Detection of mutations in the dystrophin gene via automated DHPLC screening and direct sequencing
U.S. Department of Health & Human Services —
Background Currently molecular diagnostic laboratories focus only on the identification of large deletion and duplication mutations (spanning one exon or more) for... -
Federal
Saline lavage with substitution of bovine surfactant in term neonates with meconium aspiration syndrome (MAS) transferred for extracorporeal membrane oxygenation (ECMO): a pilot study
U.S. Department of Health & Human Services —
Background: Meconium aspiration syndrome (MAS) is still a condition associated with a high mortality, and many patients require extracorporeal membrane oxygenation... -
Federal
Acquisition of tolerance against oxidative damage in
U.S. Department of Health & Human Services —
Background Living cells constantly sense and adapt to redox shifts by the induction of genes whose products act to maintain the cellular redox environment. In the... -
Federal
The Metal Coordination of sCD39 during ATP Hydrolysis
U.S. Department of Health & Human Services —
Background The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. In spite of... -
Federal
Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state
U.S. Department of Health & Human Services —
Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state -
Federal
Annotated Bibliography on Equity in Health, 1980-2001
U.S. Department of Health & Human Services —
The purposes of this bibliography are to present an overview of the published literature on equity in health and to summarize key articles relevant to the mission of... -
Federal
Multi site polyadenylation and transcriptional response to stress of a vacuolar type H
U.S. Department of Health & Human Services —
Background Vacuolar type H+-ATPases play a critical role in the maintenance of vacuolar homeostasis in plant cells. V-ATPases are also involved in plants' defense... -
Federal
Multi-exon deletions of the
U.S. Department of Health & Human Services —
Background Mutations in the fibrillin -1 gene (FBN1) cause Marfan syndrome (MFS), an autosomal dominant multi-system connective tissue disorder. The 200 different... -
Federal
Upregulation of the SERCA-type Ca
U.S. Department of Health & Human Services —
Background Ca2+-ATPases of endoplasmic reticulum (SERCAs) are responsible for maintenance of the micro- to millimolar Ca2+ ion concentrations within the endoplasmic...