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Federal
Molecular action of methotrexate in inflammatory diseases
U.S. Department of Health & Human Services —
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed... -
Federal
Platelet count and Interleukin 6 Gene polymorphism in healthy subjects
U.S. Department of Health & Human Services —
Background Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on... -
Federal
Modeling of failure mode in knee ligaments depending on the strain rate
U.S. Department of Health & Human Services —
Background The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee.... -
Federal
Cellular senescence:ex vivop53-dependent asymmetric cell kinetics
U.S. Department of Health & Human Services —
Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species... -
Federal
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)
U.S. Department of Health & Human Services —
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of... -
Federal
Little qualitative RNA misexpression in sterile male F
U.S. Department of Health & Human Services —
Background Although the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles... -
Federal
Phospholipase Cδ regulates germination of
U.S. Department of Health & Human Services —
Background Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single... -
Federal
Early immune development, atopy and asthma: insights from ATS 2001, May 18-23, San Francisco
U.S. Department of Health & Human Services —
There is rising evidence that the initiation of atopy and asthma may occur in early life or even during fetal life. At the American Thoracic Society meeting 2001 in... -
Federal
13th Annual Congress of the European Society of Intensive Care Medicine, Rome, Italy, 1-4 October 2000
U.S. Department of Health & Human Services —
13th Annual Congress of the European Society of Intensive Care Medicine, Rome, Italy, 1-4 October 2000 -
Federal
Binding of the baculovirus very late expression factor 1 (VLF-1) to different DNA structures
U.S. Department of Health & Human Services —
Background Baculovirus genomes encode a gene called very late expression factor 1 (VLF-1) that is a member of the integrase (Int) family of proteins. In this report... -
Federal
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes
U.S. Department of Health & Human Services —
Background It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has... -
Federal
The evaluation of yeast derivatives as adjuvants for the immune response to the Bm86 antigen in cattle
U.S. Department of Health & Human Services —
Background The Gavac™ vaccine against the cattle tick Boophilus microplus has proven its efficacy in a large number of controlled and field experiments. However, this... -
Federal
Conceptual framework of public health surveillance and action and its application in health sector reform
U.S. Department of Health & Human Services —
Background Because both public health surveillance and action are crucial, the authors initiated meetings at regional and national levels to assess and reform... -
Federal
A clustering method for repeat analysis in DNA sequences
U.S. Department of Health & Human Services —
Background A computational system for analysis of the repetitive structure of genomic sequences is described. The method uses suffix trees to organize and search the... -
Federal
Clinical applicability of molecular biology: the case of the long QT syndrome
U.S. Department of Health & Human Services —
The clinical applicability of molecular cardiology has been questioned at length and by many clinical investigators. The congenital long QT syndrome (LQTS) provides... -
Federal
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions
U.S. Department of Health & Human Services —
Background The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia... -
Federal
Regular use of aspirin and pancreatic cancer risk
U.S. Department of Health & Human Services —
Background Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and... -
Federal
Early glandular neoplasia of the lung
U.S. Department of Health & Human Services —
Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early... -
Federal
Noninvasive positive pressure ventilation as treatment for acute respiratory failure in critically ill patients
U.S. Department of Health & Human Services —
Our current state of knowledge on noninvasive positive pressure ventilation (NPPV) and technical aspects are discussed in the present review. In patients with chronic...