10 datasets found
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Federal
Genomic approaches to research in pulmonary hypertension
U.S. Department of Health & Human Services —
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic... -
Federal
Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study
U.S. Department of Health & Human Services —
Background: The aim of this prospective study was to assess whether the presence of septic shock could influence the dose response to inhaled nitric oxide (NO) in NO-... -
Federal
Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilation
U.S. Department of Health & Human Services —
Background: This study was designed to evaluate the effect of nitric oxide (NO) on the management of neonates with severe persistent pulmonary hypertension refractory... -
Federal
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension
U.S. Department of Health & Human Services —
Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology... -
Federal
Role of endothelin-1 in lung disease
U.S. Department of Health & Human Services —
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of... -
Federal
Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension
U.S. Department of Health & Human Services —
Background The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model... -
Federal
Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis
U.S. Department of Health & Human Services —
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary... -
Federal
Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results
U.S. Department of Health & Human Services —
Background: In order to test the hypothesis that inhaled nitric oxide (NO) reverses the pulmonary hypertension induced by αα-diaspirin crosslinked hemoglobin (ααHb),... -
Federal
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
U.S. Department of Health & Human Services —
Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in... -
Federal
Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension
U.S. Department of Health & Human Services —
Introduction The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange. The aim of this...
10 datasets found