The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro
Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:20" ] |
| contactPoint |
{ "fn": "TMBB/HELD/NIOSH", "@type": "vcard:Contact", "hasEmail": "mailto:sa-cin-webteam@cdc.gov" } |
| description | Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages. |
| distribution |
[ { "@type": "dcat:Distribution", "mediaType": "application/x-zip-compressed", "downloadURL": "https://data.cdc.gov/download/3ix4-m2h6/application/x-zip-compressed" } ] |
| identifier | https://data.cdc.gov/api/views/3ix4-m2h6 |
| issued | 2025-02-18 |
| keyword |
[ "untagged" ] |
| landingPage | https://data.cdc.gov/d/3ix4-m2h6 |
| license | http://opendefinition.org/licenses/odc-odbl/ |
| modified | 2026-01-14 |
| programCode |
[ "009:034" ] |
| publisher |
{ "name": "Centers for Disease Control and Prevention", "@type": "org:Organization" } |
| theme |
[ "National Institute for Occupational Safety and Health" ] |
| title | The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro |
