{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:20"], "contactPoint": {"@type": "vcard:Contact", "fn": "TMBB/HELD/NIOSH", "hasEmail": "mailto:sa-cin-webteam@cdc.gov"}, "description": "Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages.", "distribution": [{"@type": "dcat:Distribution", "downloadURL": "https://data.cdc.gov/download/3ix4-m2h6/application/x-zip-compressed", "mediaType": "application/x-zip-compressed"}], "identifier": "https://data.cdc.gov/api/views/3ix4-m2h6", "issued": "2025-02-18", "keyword": ["untagged"], "landingPage": "https://data.cdc.gov/d/3ix4-m2h6", "license": "http://opendefinition.org/licenses/odc-odbl/", "modified": "2026-01-14", "programCode": ["009:034"], "publisher": {"@type": "org:Organization", "name": "Centers for Disease Control and Prevention"}, "theme": ["National Institute for Occupational Safety and Health"], "title": "The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro"}