The Tanana River and Big Delta airborne magnetic and radiometric geophysical survey covers parts of the Big Delta, Charley River, Circle, Eagle, Fairbanks, Kantishna River, Livengood, Mount Hayes, and Tanacross quadrangles near Fairbanks and Delta Junction, Alaska. Magnetic and radiometric data were collected with a fixed-wing aircraft from May 14 to August 4, 2022, by MPX Geophysics LTD. The survey contains six individual blocks. A total of 97,386 line kilometers were collected. The six blocks total 33,095 km2; they cover 32,944 km2 due to overlap. The magnetometer was mounted to a rear-facing fixed boom (tail stinger). The radiometric crystals were located in the cabin of the aircraft. The Tanana, Chena, Healy, Eisen, and North Pole blocks were flown with a line spacing of 400 meters (m). Mean ground clearances were: Tanana, 188 m; Chena, 352 m; Healy, 295 m; Eisen, 430 m; North Pole, 180 m. The Eisen Infill block was flown with a line spacing of 200 m and a mean ground clearance of 422 m. The data, as well as additional metadata, are available from the DGGS website: http://doi.org/10.14509/30899.