White-nose syndrome (WNS), a fungal disease that has caused catastrophic population declines of bats in eastern North America, is rapidly spreading across the continent and now threatens previously unexposed bat species in western North America. The causal agent of WNS, Pseudogymnoascus destructans, can infect many species of hibernating bats, but susceptibility to WNS varies by host species. Predicting which western bat species will be most susceptible to WNS would be of great value for establishing conservation priorities. We previously reported that certain traits of the skin microbiome of bat species in eastern North America were strongly associated with tolerance to WNS. Using these traits, we developed a model to predict WNS susceptibility of 13 species of western North American bats. Based on the model, only two bat species, Myotis velifer and Eptesicus fuscus, were predicted to be WNS-tolerant. If accurate, a greater proportion of western bat species will be susceptible to the disease compared to eastern bat species, indicating that WNS may pose a significant conservation threat in western North America.