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Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:47 AM | Dataset Last Updated: November 04, 2021
Here are all of the data files used for this manuscript. Please note that this is all published data. Imran Shah 1.1060+ Chemicals and Chemical controls 2. Chemical descriptors (chm): 2048 Morgan (mrgn) 2048 Topological Torsion (tptr) 729 ToxPrints (toxp) 3. Transcriptomic descriptors(bio): 95 Gene (ge) 189 Assay (asy) 4. 922 Toxicity outcomes(tox) 5. 86 Predefined Chemical Clusters

Resources

6 resources available

  • https://github.com/i-shah/genra-ltea

    FILE
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  • S1-tox.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • S2-bio.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • S3-bio.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • S3-clust.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • S7-chem.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Imran Shah",
  "hasEmail": "mailto:shah.imran@epa.gov"
}
description Here are all of the data files used for this manuscript. Please note that this is all published data. Imran Shah 1.1060+ Chemicals and Chemical controls 2. Chemical descriptors (chm): 2048 Morgan (mrgn) 2048 Topological Torsion (tptr) 729 ToxPrints (toxp) 3. Transcriptomic descriptors(bio): 95 Gene (ge) 189 Assay (asy) 4. 922 Toxicity outcomes(tox) 5. 86 Predefined Chemical Clusters
distribution 
[
  {
    "title": "https://github.com/i-shah/genra-ltea",
    "accessURL": "https://github.com/i-shah/genra-ltea"
  },
  {
    "title": "S1-tox.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524247/S1-tox.xlsx"
  },
  {
    "title": "S2-bio.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524247/S2-bio.xlsx"
  },
  {
    "title": "S3-bio.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524247/S3-bio.xlsx"
  },
  {
    "title": "S3-clust.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524247/S3-clust.xlsx"
  },
  {
    "title": "S7-chem.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524247/S7-chem.xlsx"
  }
]
identifier https://doi.org/10.23719/1524247
keyword 
[
  "Models",
  "chemical safety research",
  "curated data",
  "pharmacokinetics"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2021-11-04
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
null
rights 
null
title Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data

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