Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with Influenza A virus
An experimental challenge of Influenza A virus in genetically modified TMPRSS2 knockout pigs.
Resources in this dataset:
Resource Title: Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with Influenza A virus
File Name: TMPRSS2 dataset.xlsx
Resource Description: Supporting data for: Nasal shedding of A/swine/Iowa/A02524480/2020 (IA/20) H1N1 by virus titration on cell culture or qRT-PCR; Infection of IA/20 H1N1 in WT and TMPRSS2-/- pigs; Immunohistochemical (IHC) staining of Influenza A virus nucleoprotein; Cytokine and chemokine panel performed on bronchioalveolar lavage fluid.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "005:18" ] |
| contactPoint |
{ "fn": "Baker, Amy L.", "hasEmail": "mailto:amy.l.baker@usda.gov" } |
| description | <p>An experimental challenge of Influenza A virus in genetically modified TMPRSS2 knockout pigs.</p> <p>Resources in this dataset:</p> <ul> <li>Resource Title: Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with Influenza A virus File Name: TMPRSS2 dataset.xlsx Resource Description: Supporting data for: Nasal shedding of A/swine/Iowa/A02524480/2020 (IA/20) H1N1 by virus titration on cell culture or qRT-PCR; Infection of IA/20 H1N1 in WT and TMPRSS2-/- pigs; Immunohistochemical (IHC) staining of Influenza A virus nucleoprotein; Cytokine and chemokine panel performed on bronchioalveolar lavage fluid.</li> </ul><p></p> |
| distribution |
[ { "@type": "dcat:Distribution", "title": "TMPRSS2 dataset.xlsx", "format": "xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://ndownloader.figshare.com/files/43757148" } ] |
| identifier | 10.15482/USDA.ADC/1529793 |
| keyword |
[ "ARS", "Influenza A virus", "NP103", "Swine", "TMPRSS2", "data.gov", "disease resistance" ] |
| license | https://www.usa.gov/publicdomain/label/1.0/ |
| modified | 2025-11-21 |
| programCode |
[ "005:040" ] |
| publisher |
{ "name": "Agricultural Research Service", "@type": "org:Organization" } |
| spatial |
"{"type": "Point", "coordinates": [-93.617248535156, 42.044002396934]}"
|
| temporal | 2022-10-01/2023-05-31 |
| title | Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with Influenza A virus |
