Patent AT-E401054-T1: [Translated] LIQUID DEPOSIT FORMULATIONS
The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of:a) at least one neutral diacyl lipid and/or at least one tocopherol;b) at least one phospholipid;c) at least one biocompatible, oxygen containing, low viscosity organic solvent;wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.
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| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH/NCBI Data Team", "@type": "vcard:Contact", "hasEmail": "mailto:info@ncbi.nlm.nih.gov" } |
| description | The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of:a) at least one neutral diacyl lipid and/or at least one tocopherol;b) at least one phospholipid;c) at least one biocompatible, oxygen containing, low viscosity organic solvent;wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Data Source", "mediaType": "text/html", "description": "Access the complete Patent AT-E401054-T1: [Translated] LIQUID DEPOSIT FORMULATIONS on the official website.", "downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401054-T1" } ] |
| identifier | https://healthdata.gov/api/views/c9ud-wvv6 |
| issued | 2025-09-05 |
| keyword |
[ "chemistry", "innovation", "patent", "pubchem", "research" ] |
| landingPage | https://healthdata.gov/d/c9ud-wvv6 |
| modified | 2025-09-06 |
| programCode |
[ "009:066" ] |
| publisher |
{ "name": "National Center for Biotechnology Information (NCBI)", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Patent AT-E401054-T1: [Translated] LIQUID DEPOSIT FORMULATIONS |
