In support of U.S. Geological Survey (USGS) Southwest Biological Science Center researchers, and in coordination with the Bureau of Land Management (BLM) and National Ecological Observatory Network (NEON), the USGS National Uncrewed Systems Office (NUSO) conducted uncrewed aircraft systems (UAS) remote sensing flights over two BLM Assessment, Inventory, and Monitoring (AIM) plots at the NEON Moab site in Utah for multi-scale carbon sequestration research on public lands. The UAS data collected include natural color, multispectral, and hyperspectral imagery, and lidar to capture diverse information about vegetation and soils on drylands. The first site (“site 1”) features intact sagebrush and was mapped on May 3, 2023. The second site (“site 7”) is located on a grazed rangeland environment and was mapped on May 5, 2023. These UAS surveys were conducted in early May 2023 to coincide spatially and temporally with ground-based BLM AIM sampling and airplane-based remote sensing surveys by NEON. This portion of the data release presents multispectral data products from low-altitude UAS flights at two dryland sites approximately 40 km south of Moab, Utah. A DJI Matrice 600 Pro UAS with approved government edition firmware carrying an AgEagle MicaSense Altum-PT sensor was flown at an altitude of 31 meters above ground level to capture multispectral imagery. Survey control was established using Propeller AeroPoint temporary ground control points (GCPs) distributed throughout the survey area. GCPs were post-processed with corrections from a concurrently operating Trimble R8s GNSS base station. Multispectral images were processed in photogrammetry software using the GCPs to yield structure-from-motion (SfM) point clouds (.las format), digital surface models (DSM, in .tif format), and 5-band orthomosaics (.tif format). The 5-band orthomosaics were radiometrically calibrated to units of reflectance in each spectral band (blue, green, red, red edge, and near infrared) spanning the visible and near infrared wavelengths, 475 – 842 nm.