A three-dimensional groundwater flow model (MODFLOW2000) of the Atlantic Coastal Plain aquifers and confining units was developed to evaluate groundwater availability and to forecast the potential effects of climate change on groundwater levels in the study area. Two existing groundwater flow models that simulated flow and water use in the Coastal Plain aquifers of North Carolina (NC), South Carolina (SC), and parts of Georgia and Virginia, were combined and updated to provide a single model. Revisions to the model incorporated additional hydrogeologic, geologic, water-level, and water-use data and hydrogeologic inconsistencies at the NC-SC border reconciled since the development of the previous models. The new model simulates groundwater flow at regional and intermediate special scales superimposed on a transient time scale from 1900 to 2004. This USGS data release contains all of the input and output files for the simulation and calibration described in the associated model documentation report (https://pubs.er.usgs.gov/publication/pp1773).