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HTTK: R Package for High-Throughput Toxicokinetics
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) . Chemical-specific in vitro data have been obtained from relatively high throughput experiments. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code.
This dataset is associated with the following publication:
Pearce , R., C. Strope , W. Setzer , N. Sipes , and J. Wambaugh. (Journal of Statistical Software) HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, USA, 79(4): 1-26, (2017).
Resources
1 resource available
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https://cran.r-project.org/web/packages/httk/index.html
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Alexander Hanf", "hasEmail": "mailto:hanf.alexander@epa.gov" } |
| description | Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) <doi:10.18637/jss.v079.i04>. Chemical-specific in vitro data have been obtained from relatively high throughput experiments. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. This dataset is associated with the following publication: Pearce , R., C. Strope , W. Setzer , N. Sipes , and J. Wambaugh. (Journal of Statistical Software) HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, USA, 79(4): 1-26, (2017). |
| distribution |
[ { "title": "https://cran.r-project.org/web/packages/httk/index.html", "accessURL": "https://cran.r-project.org/web/packages/httk/index.html" } ] |
| identifier | https://doi.org/10.23719/1504255 |
| keyword |
[ "ExpoCast", "ToxCast", "exposure", "high-throughput", "httk", "pharmacokinetics" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2017-07-17 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.18637/jss.v079.i04" ] |
| rights |
null
|
| title | HTTK: R Package for High-Throughput Toxicokinetics |
