Dataset is about the HSI Operation Popeye which was conducted in collaboration with partners in Italy, Colombia, and the United States to dismantle multiple organized crime groups operating in domestically and in Europe, while simultaneously disrupting a Colombian drug cartel representing one of the largest suppliers of cocaine and fentanyl to Europe and North America. Operation Popeye led to the seizure of 4.4 tons of cocaine, 66 kilograms of heroin, €1.85 million (approximately $2.04 million), and 63 arrests. This investigation leveraged HSI’s unique domestic and international authorities and resources to coordinate one of the largest and most complex undercover operations ever accomplished through United States and international law enforcement partnerships.