Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans
An investigation of antigenic relationships between North American swine H3N2 influenza A viruses (IAV) and human seasonal vaccine strains was conducted to assess the zoonotic risk to humans. Human seasonal H3N2 vaccine strains isolated from 1973 to 2014 (n=20) were obtained from the World Health Organization Global Influenza Surveillance and Response Network through St. Jude Children’s Research Hospital to use for serological assays, such as hemagglutination inhibition (HI) assays. Human seasonal vaccine strains were cultured on MDCK cells or eggs and the HA gene was verified by sequencing on a Sanger method at National Animal Disease Center (NADC). A consensus HA sequence was generated using Geneious Software.
Resources in this dataset:Resource Title: Consensus sequences of hemagglutinin (HA) gene segments. File Name: Vincent_H3N2 HuVac strains.rtfResource Description: The data set includes sequences of hemagglutinin (HA) gene of human seasonal influenza A vaccine strains used in hemagglutination inhibition (HI) assays as references to assess the zoonotic risk of North American swine H3N2 strains to humans. The text file lists the consensus sequence of HA gene segment from each human H3N2 influenza A vaccine strain.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "005:18" ] |
| contactPoint |
{ "fn": "Vincent, Amy L.", "hasEmail": "mailto:amy.vincent@usda.gov" } |
| description | <p>An investigation of antigenic relationships between North American swine H3N2 influenza A viruses (IAV) and human seasonal vaccine strains was conducted to assess the zoonotic risk to humans. Human seasonal H3N2 vaccine strains isolated from 1973 to 2014 (n=20) were obtained from the World Health Organization Global Influenza Surveillance and Response Network through St. Jude Children’s Research Hospital to use for serological assays, such as hemagglutination inhibition (HI) assays. Human seasonal vaccine strains were cultured on MDCK cells or eggs and the HA gene was verified by sequencing on a Sanger method at National Animal Disease Center (NADC). A consensus HA sequence was generated using Geneious Software.</p> <div><br>Resources in this dataset:</div><br><ul><li><p>Resource Title: Consensus sequences of hemagglutinin (HA) gene segments.</p> <p>File Name: Vincent_H3N2 HuVac strains.rtf</p><p>Resource Description: The data set includes sequences of hemagglutinin (HA) gene of human seasonal influenza A vaccine strains used in hemagglutination inhibition (HI) assays as references to assess the zoonotic risk of North American swine H3N2 strains to humans. The text file lists the consensus sequence of HA gene segment from each human H3N2 influenza A vaccine strain. </p></li></ul> |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Vincent_H3N2 HuVac strains.rtf", "format": "rtf", "mediaType": "text/rtf", "downloadURL": "https://ndownloader.figshare.com/files/44529488" } ] |
| identifier | 10.15482/USDA.ADC/1522389 |
| keyword |
[ "ARS", "H3N2", "NP103", "antigenic cartography", "data.gov", "human vaccine", "influenza" ] |
| license | https://www.usa.gov/publicdomain/label/1.0/ |
| modified | 2025-11-21 |
| programCode |
[ "005:040" ] |
| publisher |
{ "name": "Agricultural Research Service", "@type": "org:Organization" } |
| spatial |
"{"type": "Polygon", "coordinates": [[[-165.76171875, 25.572175556682], [-165.76171875, 71.995974056837], [-51.85546875, 71.995974056837], [-51.85546875, 25.572175556682], [-165.76171875, 25.572175556682]]]}"
|
| temporal | 1973-01-01/2014-12-31 |
| title | Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans |
