Skip to main content
U.S. flag

An official website of the United States government

Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:48 AM | Dataset Last Updated: November 16, 2021
Whole transcriptomics dose response data is collected and storedthrough public facing Gene Expression Omnibus database. Raw collected viability/cytotoxicity data for each chemical are collected and presented on separate spreadsheets. Portions of this dataset are inaccessible because: The transcriptomics full data file is too large to be uploaded alone onto ScienceHub, impeding ease of access. They can be accessed through the following means: Raw and processed transcriptomics data is available through Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/) under accession GSE199794. Format: The full transcriptomics data set for all chemical conditions tested. This dataset is associated with the following publication: Speen, A., J. Murray, T. Krantz, D. Davies, P. Evansky, J. Harrill, L. Everett, J. Bundy, L. Dailey, W. Zander, E. Carlsten, M. Monsees, J. Hill, J. Zavala, and M. Higuchi. Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(1): 88-107, (2022).

Resources

8 resources available

  • 1,3-butadiene Sample ID and exposure conditions.xlsx

    XLSX
    Download

  • 1-Bromopropane Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

  • Acetaldehyde Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

  • Acrolein Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

  • Carbon Tetrachloride Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

  • Dichloromethane Sample ID and Exposure Conditions1.xlsx

    XLSX
    Download

  • Formaldehyde Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

  • Trichloroethylene Sample ID and Exposure Conditions.xlsx

    XLSX
    Download

Find Related Datasets

Search by Tags

Click any tag below to search for similar datasets

Complete Metadata
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Mark Higuchi",
  "hasEmail": "mailto:higuchi.mark@epa.gov"
}
description Whole transcriptomics dose response data is collected and storedthrough public facing Gene Expression Omnibus database. Raw collected viability/cytotoxicity data for each chemical are collected and presented on separate spreadsheets. Portions of this dataset are inaccessible because: The transcriptomics full data file is too large to be uploaded alone onto ScienceHub, impeding ease of access. They can be accessed through the following means: Raw and processed transcriptomics data is available through Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/) under accession GSE199794. Format: The full transcriptomics data set for all chemical conditions tested. This dataset is associated with the following publication: Speen, A., J. Murray, T. Krantz, D. Davies, P. Evansky, J. Harrill, L. Everett, J. Bundy, L. Dailey, W. Zander, E. Carlsten, M. Monsees, J. Hill, J. Zavala, and M. Higuchi. Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(1): 88-107, (2022).
distribution 
[
  {
    "title": "1,3-butadiene Sample ID and exposure conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/1%2C3-butadiene%20Sample%20ID%20and%20exposure%20conditions.xlsx"
  },
  {
    "title": "1-Bromopropane Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/1-Bromopropane%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  },
  {
    "title": "Acetaldehyde Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Acetaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  },
  {
    "title": "Acrolein Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Acrolein%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  },
  {
    "title": "Carbon Tetrachloride Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Carbon%20Tetrachloride%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  },
  {
    "title": "Dichloromethane Sample ID and Exposure Conditions1.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Dichloromethane%20Sample%20ID%20and%20Exposure%20Conditions1.xlsx"
  },
  {
    "title": "Formaldehyde Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Formaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  },
  {
    "title": "Trichloroethylene Sample ID and Exposure Conditions.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1524251/Trichloroethylene%20Sample%20ID%20and%20Exposure%20Conditions.xlsx"
  }
]
identifier https://doi.org/10.23719/1524251
keyword 
[
  "Volatile organic compound (VOC)",
  "airway epithelial cells",
  "transcriptomics"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2021-11-16
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1093/toxsci/kfac040"
]
rights 
null
title Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System

data.gov

An official website of the GSA's Technology Transformation Services

Looking for U.S. government information and services?
Visit USA.gov