Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue
Acute-phase serum amyloid A (A-SAA) is a major component of the
acute-phase response. A sustained acute-phase response in rheumatoid arthritis
(RA) is associated with increased joint damage. A-SAA mRNA expression was
confirmed in all samples obtained from patients with RA, but not in normal
synovium. A-SAA mRNA expression was also demonstrated in cultured RA
synoviocytes. A-SAA protein was identified in the supernatants of primary
synoviocyte cultures, and its expression colocalized with sites of macrophage
accumulation and with some vascular endothelial cells. It is concluded that
A-SAA is produced by inflamed RA synovial tissue. The known
association between the acute-phase response and progressive joint damage may
be the direct result of synovial A-SAA-induced effects on cartilage
degradation.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH", "@type": "vcard:Contact", "hasEmail": "mailto:info@nih.gov" } |
| description | Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Government Data Source", "mediaType": "text/html", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17807/" } ] |
| identifier | https://healthdata.gov/api/views/hrbk-n84y |
| issued | 2025-07-13 |
| keyword |
[ "acute-phase-response", "nih", "rheumatoid-arthritis", "serum-amyloid-a", "synovial-tissue" ] |
| landingPage | https://healthdata.gov/d/hrbk-n84y |
| modified | 2025-09-06 |
| programCode |
[ "009:033" ] |
| publisher |
{ "name": "National Institutes of Health", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue |
