{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Acute-phase serum amyloid A (A-SAA) is a major component of the\n\t\t\t acute-phase response. A sustained acute-phase response in rheumatoid arthritis\n\t\t\t (RA) is associated with increased joint damage. A-SAA mRNA expression was\n\t\t\t confirmed in all samples obtained from patients with RA, but not in normal\n\t\t\t synovium. A-SAA mRNA expression was also demonstrated in cultured RA\n\t\t\t synoviocytes. A-SAA protein was identified in the supernatants of primary\n\t\t\t synoviocyte cultures, and its expression colocalized with sites of macrophage\n\t\t\t accumulation and with some vascular endothelial cells. It is concluded that\n\t\t\t A-SAA is produced by inflamed RA synovial tissue. The known\n\t\t\t association between the acute-phase response and progressive joint damage may\n\t\t\t be the direct result of synovial A-SAA-induced effects on cartilage\n\t\t\t degradation.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17807/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/hrbk-n84y", "issued": "2025-07-13", "keyword": ["acute-phase-response", "nih", "rheumatoid-arthritis", "serum-amyloid-a", "synovial-tissue"], "landingPage": "https://healthdata.gov/d/hrbk-n84y", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Acute-phase serum amyloid A production by rheumatoid arthritis\n\t\t  synovial tissue"}