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3 datasets found

Federal

Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

U.S. Department of Health & Human Services —

Background The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth...
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Federal

HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

U.S. Department of Health & Human Services —

Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing...
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Federal

Deficiency ofPtenaccelerates mammary oncogenesis in MMTV-Wnt-1transgenic mice

U.S. Department of Health & Human Services —

Germline mutations in the tumor suppressorPTENpredispose human beings to breast cancer, and genetic and epigenetic alterations ofPTENare also detected in sporadic...
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3 datasets found

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