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Federal
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo
U.S. Department of Health & Human Services —
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive... -
Federal
Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth
U.S. Department of Health & Human Services —
Background The outgrowth of new vessels – angiogenesis – in the tumour mass is considered to be a limiting factor of tumour growth. To inhibit the matrix lysis that... -
Federal
Role of arginine and its methylated derivatives in cancer biology and treatment
U.S. Department of Health & Human Services —
Both L-arginine supplementation and deprivation influence cell proliferation. The effect of high doses on tumours is determined by the optical configuration:...