7 datasets found
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Federal
Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation
U.S. Department of Health & Human Services —
Background Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing... -
Federal
IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?
U.S. Department of Health & Human Services —
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months... -
Federal
Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice
U.S. Department of Health & Human Services —
Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a... -
Federal
Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle
U.S. Department of Health & Human Services —
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the... -
Federal
Association of MHC and rheumatoid arthritis: Regulatory role of HLA class II molecules in animal models of RA - studies on transgenic/knockout mice
U.S. Department of Health & Human Services —
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ... -
Federal
An efficient method to successively introduce transgenes into a given genomic locus in the mouse
U.S. Department of Health & Human Services —
Background Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability... -
Federal
Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal
U.S. Department of Health & Human Services —
Background Non-invasive autofluorescent reporters have revolutionized lineage labeling in an array of different organisms. In recent years green fluorescent protein...
7 datasets found