9 datasets found
-
Federal
B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus
U.S. Department of Health & Human Services —
B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights in particular the... -
Federal
Risk for rheumatic disease in relation to ethnicity and admixture
U.S. Department of Health & Human Services —
Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans... -
Federal
IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?
U.S. Department of Health & Human Services —
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months... -
Federal
Autologous stem-cell transplantation in refractory autoimmune diseases after
U.S. Department of Health & Human Services —
Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete... -
Federal
Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham
U.S. Department of Health & Human Services —
Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the... -
Federal
Links between complement deficiency and apoptosis
U.S. Department of Health & Human Services —
Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition,... -
Federal
Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus
U.S. Department of Health & Human Services —
To assess the impact of somatic hypermutation and selective influences on the Vλ light chain repertoire in systemic lupus erythematosus (SLE), the frequency and... -
Federal
Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus
U.S. Department of Health & Human Services —
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome... -
Federal
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
U.S. Department of Health & Human Services —
Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect...
9 datasets found