6 datasets found
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Federal
“The influence of control group reproduction on the statistical power of the Environmental Protection Agency’s Medaka Extended One Generation Reproduction Test (MEOGRT) data for simulations” Dataset
U.S. Environmental Protection Agency —
Excel spreadsheet that contains the raw fecundity data used to conduct power simulations specific to the MEOGRT reproductive assessment. This dataset is associated... -
Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this... -
Federal
Prominent medical journals often provide insufficient information to assess the validity of studies with negative results
U.S. Department of Health & Human Services —
Background Physicians reading the medical literature attempt to determine whether research studies are valid. However, articles with negative results may not provide... -
Federal
Analysis of proportional data in reproductive and developmental toxicity studies: comparison of logit transformation, arcsine square root transformation, and nonparametric analysis
U.S. Environmental Protection Agency —
We conducted power calculations to compare different approaches (nonparametric, arcsine square root-transformed, logit-transformed, untransformed) for analyzing... -
Federal
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
U.S. Department of Health & Human Services —
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power,... -
Federal
How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
U.S. Department of Health & Human Services —
Background It has been recognized that replicates of arrays (or spots) may be necessary for reliably detecting differentially expressed genes in microarray...
6 datasets found