8 datasets found
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Federal
Debate: "How low should LDL cholesterol be lowered?" Viewpoint: "It doesn't need to be very low"
U.S. Department of Health & Human Services —
The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials... -
Federal
Debate: Statins should be used in patients with heart failure
U.S. Department of Health & Human Services —
Treatment to prevent progression of heart failure has been targeted to reverse the consequences of heart failure and to a lesser extent the cause – the... -
Federal
The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice
U.S. Department of Health & Human Services —
The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in... -
Federal
Are statins anti-inflammatory?
U.S. Department of Health & Human Services —
Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may... -
Federal
The role of statins as potential targets for bone formation
U.S. Department of Health & Human Services —
Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In... -
Federal
Statins as modulators of bone formation
U.S. Department of Health & Human Services —
The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that... -
Federal
Debate: Should statin be used in patients with heart failure?
U.S. Department of Health & Human Services —
Statins reduce mortality of patients with coronary artery disease (CAD). However, by protocol, trials have excluded patients with chronic heart failure. Since the... -
Federal
The role of dyslipidemia and statins in venous thromboembolism
U.S. Department of Health & Human Services —
Recent studies have proposed an association between hyperlipidemia and venous thromboembolism (VTE). We review the epidemiological evidence linking dyslipidemia with...
8 datasets found