81 datasets found
-
Federal
Research Article: Arthritis Research
U.S. Department of Health & Human Services —
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major... -
Federal
Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction
U.S. Department of Health & Human Services —
Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction -
Federal
Fibroblast biology: Signals targeting the synovial fibroblast in arthritis
U.S. Department of Health & Human Services —
Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to... -
Federal
Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines
U.S. Department of Health & Human Services —
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and... -
Federal
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset
U.S. Department of Health & Human Services —
An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year... -
Federal
B cells in rheumatoid arthritis
U.S. Department of Health & Human Services —
Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of... -
Federal
Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
U.S. Department of Health & Human Services —
Objective To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.... -
Federal
Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis
U.S. Department of Health & Human Services —
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular... -
Federal
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis
U.S. Department of Health & Human Services —
IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression... -
Federal
Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications
U.S. Department of Health & Human Services —
Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three... -
Federal
Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases
U.S. Department of Health & Human Services —
Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial... -
Federal
Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction
U.S. Department of Health & Human Services —
In the present study, we searched for mutant PTEN transcripts in aggressive rheumatoid arthritis synovial fibroblasts (RA-SF) and studied the expression of PTEN in... -
Federal
Advances in Targeted Therapies III, Nassau, Bahamas, 27 April-1 May 2001
U.S. Department of Health & Human Services —
This conference was the third in a series focusing on developments in the therapy of rheumatoid arthritis (RA) and other rheumatic conditions with biologicals; in... -
Federal
IFN-γ production in response to
U.S. Department of Health & Human Services —
IFN-γ was measured in supernatants after in vitro stimulation of peripheral blood mononuclear cells with collagen type II (CII), purified protein derivative or... -
Federal
Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
U.S. Department of Health & Human Services —
The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs... -
Federal
Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue
U.S. Department of Health & Human Services —
Angiopoietins (Ang) are vascular endothelial cell-specific growth factors that play important roles principally during the later stages of angiogenesis. We have... -
Federal
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells
U.S. Department of Health & Human Services —
To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from... -
Federal
Clonal expansion is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis
U.S. Department of Health & Human Services —
The present study was designed to analyze the level of B-cell clonal diversity in patients with rheumatoid arthritis by using HCDR3 (third complementarity determining... -
Federal
The effects of 1α,25-dihydroxyvitamin D
U.S. Department of Health & Human Services —
The biologically active metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], acts through vitamin D receptors, which were found in rheumatoid tissues... -
Federal
Anti-cytokine therapy in chronic destructive arthritis
U.S. Department of Health & Human Services —
Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid...
81 datasets found