5 datasets found
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Federal
Cellular senescence:ex vivop53-dependent asymmetric cell kinetics
U.S. Department of Health & Human Services —
Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species... -
Federal
Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer
U.S. Department of Health & Human Services —
Background Loss of activity of tumor suppressor genes is considered a fundamental step in a genetic model of carcinogenesis. Altered expression of the p53 and the... -
Federal
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
U.S. Department of Health & Human Services —
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing... -
Federal
p53 in rheumatoid arthritis: friend or foe?
U.S. Department of Health & Human Services —
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid... -
Federal
Genetic stabilization by p53 involves growth regulatory and repair pathways
U.S. Department of Health & Human Services —
p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor....
5 datasets found