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Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight) recent views
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
HSFA2 functions in the physiological adaptation of undifferentiated plant cells to spaceflight microgravity environment recent views
National Aeronautics and Space Administration —
The Heat Shock Factor A2 (HsfA2) as a part of the HSF network is essential to the plant s response to almost any environmental stress and to the cellular homeostatic... -
Federal
Transient gene expression profile changes of confluent human fibroblast cells in spaceflight recent views
National Aeronautics and Space Administration —
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or... -
Federal
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity recent views
National Aeronautics and Space Administration —
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We... -
Federal
Global gene expression analysis highlights microgravity sensitive key genes in soleus and EDL of 30 days space flown mice recent views
National Aeronautics and Space Administration —
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in... -
Federal
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis [Experiment 1] recent views
National Aeronautics and Space Administration —
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses... -
Federal
Biological Research in Canisters-16 (BRIC-16): Investigations of the plant cytoskeleton in microgravity with gene profiling and cytochemistry recent views
National Aeronautics and Space Administration —
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight... -
Federal
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations recent views
National Aeronautics and Space Administration —
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological... -
Federal
Response of mammary tissue to high-LET HZE particle (Silicon ions) radiation or low-LET gamma-rays recent views
National Aeronautics and Space Administration —
Transcriptional profiling of mammary tissue irradiated at 10 weeks of age with either 100 cGy sparsely ionizing gamma-rays or 10 cGy or 30 cGy densely ionizing... -
Federal
Transcription profiling of rat keratinocytes exposed to a 56Fe ion beam recent views
National Aeronautics and Space Administration —
The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a 56Fe ion beam Experiment Overall Design: The cells... -
Federal
Evaluation of in vitro macrophage differentiation during space flight recent views
National Aeronautics and Space Administration —
We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle... -
Federal
Spaceflight effects on the mouse retina: Histological gene expression and epigenetic changes after flight on STS-135 recent views
National Aeronautics and Space Administration —
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing... -
Federal
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity recent views
National Aeronautics and Space Administration —
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls.... -
Federal
Gene expression profiling in human fibroblast after low-LET irradiation recent views
National Aeronautics and Space Administration —
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate... -
Federal
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression recent views
National Aeronautics and Space Administration —
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of... -
Federal
Global DNA methylation profiling of radiation-induced rat mammary carcinomas recent views
National Aeronautics and Space Administration —
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat... -
Federal
Action of microgravity on root development recent views
National Aeronautics and Space Administration —
Arabidopsis were grown on horizontal or vertical clinostat for 4 8 or 12 days. Seedlings on horizontal clinostat were in simulated microgravity and seedlings on... -
Federal
Gene expression profiling of PBL in response to ionising radiation and modeled microgravity recent views
National Aeronautics and Space Administration —
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day recent views
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special... -
Federal
STS-135 Liver Transcriptomics recent views
National Aeronautics and Space Administration —
Mice were flown onboard STS-135 and returned to Earth for analysis. Livers were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples were...