17 datasets found
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Federal
Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)
U.S. Department of Health & Human Services —
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been... -
Federal
Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland
U.S. Department of Health & Human Services —
The mouse mammary gland may undergo cycles of proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation. Mammary... -
Federal
PFNA mouse body weight
U.S. Environmental Protection Agency —
Body weight of mice exposed to PFNA. -
Federal
Theankgene story
U.S. Department of Health & Human Services —
A landmark investigation into the genetic basis of murine progressive ankylosis has clarified the physiologic role of extracellular inorganic pyrophosphate (ePPi) in... -
Federal
Characterization of the mouse
U.S. Department of Health & Human Services —
Background DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor,... -
Federal
Role of IL-12 in
U.S. Department of Health & Human Services —
The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is... -
Federal
Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension
U.S. Department of Health & Human Services —
Background The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model... -
Federal
Blood borne transit of CJD from brain to gut at early stages of infection
U.S. Department of Health & Human Services —
Background In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which... -
Federal
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
U.S. Department of Health & Human Services —
Background Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often... -
Federal
Mouse skin passage of a
U.S. Department of Health & Human Services —
Background Streptolysin S (SLS), the oxygen-stable hemolysin of Streptococcus pyogenes, has recently been shown to be encoded by the sagA/pel gene. Mutants lacking... -
Federal
Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells
U.S. Department of Health & Human Services —
Background This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR,... -
Federal
Deficiency ofPtenaccelerates mammary oncogenesis in MMTV-Wnt-1transgenic mice
U.S. Department of Health & Human Services —
Germline mutations in the tumor suppressorPTENpredispose human beings to breast cancer, and genetic and epigenetic alterations ofPTENare also detected in sporadic... -
Federal
Cloning and characterization of the mouse
U.S. Department of Health & Human Services —
Background Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities.... -
Federal
The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it
U.S. Department of Health & Human Services —
Background Experimental colitis with features similar to inflammatory bowel disease (IBD) has initially been described. A detailed analysis of inflammatory cells has... -
Federal
Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon: Correction
U.S. Department of Health & Human Services —
Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or... -
Federal
Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer
U.S. Department of Health & Human Services —
Background It is not uncommon to observe circulating tumor antigen-specific T lymphocytes in cancer patients despite a lack of significant infiltration and... -
Federal
Tissue factor as a proinflammatory agent
U.S. Department of Health & Human Services —
Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood coagulation. TF expression on monocytes and endothelial cells is induced...
17 datasets found