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3 datasets found

Federal

A surrogate-based approach for post-genomic partner identification

U.S. Department of Health & Human Services —

Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present...
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Federal

In silico discovery of novel Retinoic Acid Receptor agonist structures

U.S. Department of Health & Human Services —

Background Several Retinoic Acid Receptors (RAR) agonists have therapeutic activity against a variety of cancer types; however, unacceptable toxicity profiles have...
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Federal

An MCASE approach to the search of a cure for Parkinson's Disease.

U.S. Department of Health & Human Services —

Background Parkinson's disease is caused by a dopamine deficiency state in the fore brain area. Dopamine receptor agonists, MAO-B inhibitors, and N-Methyl-D-Aspartate...
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3 datasets found

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