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Federal
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU) microgravity in mice: retina transcriptomic and epigenomic data
National Aeronautics and Space Administration —
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose... -
Federal
Muscle atrophy osteoporosis prevention in hibernating mammals
National Aeronautics and Space Administration —
Physical inactivity decreases the mechanical load on the skeleton which when prolonged leads to losses of muscle strength and bone mass in humans and most mammalian... -
Federal
Effect of microgravity on HUVECs (Human Umbilical vein Endothelial cells) cells and its transcriptome analysis.
National Aeronautics and Space Administration —
Adaptation of humans in low gravity conditions is a matter of utmost importance when efforts are on to a gigantic leap in human space expeditions for tourism and... -
Federal
A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space
National Aeronautics and Space Administration —
Bacterial behavior has been observed to change during spaceflight. Higher final cell counts enhanced biofilm formation increased virulence and reduced susceptibility... -
Federal
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
National Aeronautics and Space Administration —
With extended stays aboard the International Space Station (ISS) becoming commonplace there is a need to better understand the effects of microgravity on cardiac... -
Federal
Methylome Analysis of Arabidopsis Seedlings Exposed to Microgravity
National Aeronautics and Space Administration —
DNA methylation is a very important kind of epigenetic modification and participates in many biological functions. Although many previous studies have addressed... -
Federal
Global gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
National Aeronautics and Space Administration —
Efficient generation of cardiomyocytes from human pluripotent stem cells is critical for their regenerative applications. Microgravity and 3D culture can profoundly... -
Federal
miRNA signature detection and countermeasures against HZE radiation exposure for tissue degeneration-Plasma
National Aeronautics and Space Administration —
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA... -
Federal
Plasticity of the human IgM repertoire in response to a long-term spaceflight
National Aeronautics and Space Administration —
Immune dysregulation is among the main adverse outcomes of spaceflight. Despite its crucial role in host protection effects on the human antibody repertoire are... -
Federal
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity
National Aeronautics and Space Administration —
Physical forces greatly influence the growth and function of an organism. Altered gravity can perturb normal development and induce corresponding changes in gene... -
Federal
miRNA signature detection and countermeasures against HZE radiation exposure for tissue degeneration-Heart tissue
National Aeronautics and Space Administration —
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA... -
Federal
During development the Sku5 mutant roots engage different genes than wild type WS roots either on the ground or in spaceflight.
National Aeronautics and Space Administration —
The wild type WS plants and the Sku5 mutant plants in the WS background were germinated on ISS or on the ground and the gene expression profiles in roots at 4 days or... -
Federal
Murine TCR-beta repertoire sequencing
National Aeronautics and Space Administration —
The purpose of this project was to determine the effects of chronic exposure to unpredictable mild socio-environmental stressors during gestation on the TCR-beta... -
Federal
Dissecting transcriptional responses of nucleolin mutants to red light stimulation and darkness in ground reference conditions
National Aeronautics and Space Administration —
Understanding plant adaptive responses to the space environment is a requisite for enabling space farming. Spaceflight produce deleterious effects on plant cells... -
Federal
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU) microgravity in mice: brain transcriptomic and epigenomic data
National Aeronautics and Space Administration —
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose... -
Federal
Eruca sativa Rocket Science RNA-seq
National Aeronautics and Space Administration —
In the Rocket Science citizen science project Eruca sativa (salad rocket) seeds stored for six months on board of the International Space Station caused delayed crop... -
Federal
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity
National Aeronautics and Space Administration —
Physical forces greatly influence the growth and function of an organism. Altered gravity can perturb normal development and induce corresponding changes in gene... -
Federal
HARV replication of the BRIC-21 Bacillus subtilis spaceflight samples
National Aeronautics and Space Administration —
Previous spaceflight experiments using Bacillus subtilis have reported altered transcriptome profiles during spaceflight compared to matching ground samples. This... -
Federal
Plant development on ISS differs from the development on the ground and is influenced by the genetic background
National Aeronautics and Space Administration —
The development of Col-0 and WS plants on orbit differs from that on the ground as demonstrated by the comparison of the gene expression profiles between 4 days old... -
Federal
A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells
National Aeronautics and Space Administration —
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the...