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    FederalThe International Space Station Has a Unique and Extreme Microbial and Chemical Environment Driven by Use PatternsNational Aeronautics and Space Administration — Space habitation provides unique challenges in built environments isolated from Earth. We produced a 3D map of the microbes and metabolites throughout the...
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    FederalLong-read sequencing reveals increased occurrence of genomic variants and adenosine methylation in Bacillus pumilus SAFR-032 after long-duration flight exposure onboard the International Space StationNational Aeronautics and Space Administration — Bacillus pumilus SAFR-032, an endospore-forming bacterial strain, was investigated to determine its methylation pattern (methylome) change, compared to ground...
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    FederalBRIC-23 GeneLab Process Verification Test: Staphylococcus aureus transcriptomic, proteomic, and metabolomic dataNational Aeronautics and Space Administration — Microbes interact with humans in complex ways and understanding how they respond to the spaceflight environment is important to the success of future manned...
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    FederalBulk RNA sequencing and spatially resolved transcriptional profiling of cerebellums from mice flown on the RR-10 missionNational Aeronautics and Space Administration — The objective of the Rodent Research-10 mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue...
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    FederalTranscriptional profiling of thymus from mice flown on the RR-9 missionNational Aeronautics and Space Administration — The objective of the Rodent Research-9 (RR-9) mission was to use mice to understand the molecular basis of phenomena that affect astronauts during long-duration...
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    FederalFifteen days of microgravity causes growth in calvaria of mice (STS-131)National Aeronautics and Space Administration — Bone growth may occur in spaceflight as a response to skeletal unloading and head-ward fluid shifts. While unloading causes significant loss of bone mass and density...
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    FederalCharacterizing Epigenetic Changes in Methylation Mutants (elp2-5 and met1-7) in Response to Spaceflight. [RNA-Seq]National Aeronautics and Space Administration — Epigenetic changes in the DNA methylome are increasingly shown to play an integral role in regulating gene expression necessary for plants adaption to environmental...
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    FederalSpaceX Inspiration4 Stool Metagenome ProfilingNational Aeronautics and Space Administration — The SpaceX Inspiration4 mission was a 3-day mission with four private astronauts to low Earth orbit that occurred in September 2021. The crew collected biospecimen...
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    FederalCharacterization of mouse ocular responses (Microscopy) to a 35-day (RR-9) spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptationsNational Aeronautics and Space Administration — The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was...
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    FederalCharacterization of Biofilm Formation, Growth, and Gene Expression on Different Materials and Environmental Conditions in Microgravity (Morphology of Penicillium rubens biofilms)National Aeronautics and Space Administration — Microorganisms' natural ability to live as organized multicellular communities – also known as biofilms – provides them with unique survival advantages. For instance,...
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    FederalAlternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravityNational Aeronautics and Space Administration — We sought to comprehensively elucidate the transcriptomic underpinnings of microgravity-induced muscle phenotypes in mice by evaluating both differential gene...
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    FederalTranscriptional profiling of thymus from mice flown on the RR-23 missionNational Aeronautics and Space Administration — The objective of the Rodent Research-23 missions (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function...
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    FederalResponse of human lymphoblastoid cells to HZE (iron ions) or gamma-raysNational Aeronautics and Space Administration — Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiated cells with cells exposed 24 hours previously to 1.67 Gy HZE (1 GeV/amu iron ions...
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    FederalCorrelated Gene and Protein Expression in heads from Drosophila reared in microgravityNational Aeronautics and Space Administration — Omics analyses of RNA and protein isolated from heads of microgravity reared adult Drosophila.
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    FederalTranscriptional analysis of dorsal skin from mice flown on the RR-5 missionNational Aeronautics and Space Administration — The objective of the Rodent Research-5 (RR-5) study was to evaluate bone loss in mice during spaceflight and to determine if treatment with a modified version of NEL-...
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    FederalTranscriptional profiling of heart tissue from mice flown on the RRRM-2 missionNational Aeronautics and Space Administration — In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due...
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    FederalDelayed Cardiomyocyte Response to Total Body Particle Radiation Exposure - Identification of Regulatory Gene Network [iron]National Aeronautics and Space Administration — We examined molecular responses using transcriptome profiling in isolated left ventricular murine cardiomyocytes to 90 cGy, 1 GeV proton (1H) and 15 cGy, 1...
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    FederalSpace environmental factor impacts upon murine colon microbiota and mucosal homeostasisNational Aeronautics and Space Administration — We report how high and low linear energy transfer (LET) radiation, microgravity, and elevated dietary iron affect colon microbiota (determined by 16S rDNA...
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    FederalMetagenome profiling of feces from mice flown on the RRRM-1 missionNational Aeronautics and Space Administration — In Rodent Research Reference Mission-1 (RRRM-1), forty female BALB/cAnNTac mice were flown on the International Space Station. To assess differences in outcomes due...
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    FederalTranscriptional analysis of dorsal skin from mice flown on the RR-6 missionNational Aeronautics and Space Administration — The objective of the Rodent Research-6 (RR-6) study was to evaluate muscle atrophy in mice during spaceflight and to test the efficacy of a novel therapeutic to...
