146 datasets found for "Biology"
-
Federal
Critical advances in septicemia and septic shock
U.S. Department of Health & Human Services —
Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important... -
Federal
What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
U.S. Department of Health & Human Services —
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the... -
Federal
Signal analysis of behavioral and molecular cycles
U.S. Department of Health & Human Services —
Background Circadian clocks are biological oscillators that regulate molecular, physiological, and behavioral rhythms in a wide variety of organisms. While behavioral... -
Federal
Agonizing Hedgehog
U.S. Department of Health & Human Services —
It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-... -
Federal
"In-gel" purified ditags direct synthesis of highly efficient SAGE Libraries
U.S. Department of Health & Human Services —
Background SAGE (serial analysis of gene expression) is a recently developed technique for systematic analysis of eukaryotic transcriptomes. The most critical step in... -
Federal
Characterization of a protease produced by a
U.S. Department of Health & Human Services —
Background Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been... -
Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients... -
Federal
Molecular action of methotrexate in inflammatory diseases
U.S. Department of Health & Human Services —
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed... -
Federal
A functional update of the
U.S. Department of Health & Human Services —
Background Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and... -
Federal
Clinical applicability of molecular biology: the case of the long QT syndrome
U.S. Department of Health & Human Services —
The clinical applicability of molecular cardiology has been questioned at length and by many clinical investigators. The congenital long QT syndrome (LQTS) provides... -
Federal
The human Y chromosome: the biological role of a “functional wasteland”
U.S. Department of Health & Human Services —
“Functional wasteland,” “Nonrecombining desert,” and “Gene-poor chromosome” are only some examples of the different definitions given to the Y chromosome in the last... -
Federal
The evolutionary position of nematodes
U.S. Department of Health & Human Services —
Background The complete genomes of three animals have been sequenced by global research efforts: a nematode worm (Caenorhabditis elegans), an insect (Drosophila... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
Response ofEscherichia colicontaining mycobacterial carotene genes to UV radiation
U.S. Department of Health & Human Services —
Carotenoid pigments are largely distributed in nature. They are present in all of the photosynthetic organisms as well as in some bacteria, fungi, and yeast [1]. Two... -
Federal
Fibroblast biology: Effector signals released by the synovial fibroblast in arthritis
U.S. Department of Health & Human Services —
There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the... -
Federal
Autoantibody profiling for the study and treatment of autoimmune disease
U.S. Department of Health & Human Services —
Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool... -
Federal
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
U.S. Department of Health & Human Services —
Background: Protein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an... -
Federal
Vector algebra in the analysis of genome-wide expression data
U.S. Department of Health & Human Services —
Background Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these... -
Federal
What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
U.S. Department of Health & Human Services —
Reactive antigenic epitopes on presumed autoantigens of biologic interest have been examined by many researchers. The central third complementarity-determining region...
146 datasets found for "Biology"