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Federal
Severe community-acquired meningitis
U.S. Department of Health & Human Services —
Community-acquired meningitis is associated with high morbidity and mortality. The epidemiology of community-acquired meningitis has changed over the past 15 years... -
Federal
Incomplete gastric metaplasia in children with insulin-dependent diabetes mellitus and celiac disease. An ultrastructural study
U.S. Department of Health & Human Services —
Background The association of insulin-dependent diabetes mellitus (IDDM) and celiac disease (CD) has been widely reported in children but the relationship between the... -
Federal
Time course of muscle soreness following different types of exercise
U.S. Department of Health & Human Services —
Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based... -
Federal
Weight loss maintenance in women two to eleven years after participating in a commercial program: a survey
U.S. Department of Health & Human Services —
Background After 5 years, most reports show that less than 10% of people maintain a 5% loss from initial body weight. Weight maintenance after 10 years is rarely... -
Federal
What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
U.S. Department of Health & Human Services —
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the... -
Federal
Pooling, meta-analysis, and the evaluation of drug safety
U.S. Department of Health & Human Services —
Background The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
U.S. Department of Health & Human Services —
Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect... -
Federal
Protection against ultraviolet radiation by commercial summer clothing: need for standardised testing and labelling
U.S. Department of Health & Human Services —
Background The use of clothing as a means of sun protection has been recommended in recent education campaigns. Contrary to popular opinion, however, some fabrics... -
Federal
Accuracy of prognosis estimates by four palliative care teams: a prospective cohort study
U.S. Department of Health & Human Services —
Background Prognosis estimates are used to access services, but are often inaccurate. This study aimed to determine the accuracy of giving a prognosis range. Methods... -
Federal
Single-dose rofecoxib for acute postoperative pain in adults: a quantitative systematic review
U.S. Department of Health & Human Services —
Background Rofecoxib is a cyclo-oxygenase 2 selective inhibitor. This systematic review of rofecoxib in acute pain examined studies in adults of analgesic efficacy... -
Federal
New immunosuppressive drugs in heart transplantation
U.S. Department of Health & Human Services —
Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants... -
Federal
Validation and results of a questionnaire for functional bowel disease in out-patients
U.S. Department of Health & Human Services —
Background The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece. Methods This was... -
Federal
Twenty-four hour presence of physicians in the ICU
U.S. Department of Health & Human Services —
Intensive-care units (ICUs) must be utilised in the most efficient way. Greater input of intensivists leads to better outcomes and more efficient use of resources.... -
Federal
Reliability of race assessment based on the race of the ascendants: a cross-sectional study
U.S. Department of Health & Human Services —
Background Race is commonly described in epidemiological surveys based on phenotypic characteristics. Training of interviewers to identify race is time-consuming and... -
Federal
From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.
U.S. Department of Health & Human Services —
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease... -
Federal
The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians
U.S. Department of Health & Human Services —
Background An A54T polymorphism at the fatty acid binding protein 2 (FABP2) locus was found to be associated with insulin resistance in non-diabetic Pima Indians. To... -
Federal
Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis
U.S. Department of Health & Human Services —
Proteinase-3 (PR-3) is a neutral serine proteinase present in azurophil granules of human polymorphonuclear leukocytes and serves as the major target antigen of... -
Federal
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart
U.S. Department of Health & Human Services —
Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported... -
Federal
Efficacy ofHelicobacter pylorieradication therapies: a single centre observational study
U.S. Department of Health & Human Services —
ManyHelicobacter pylorieradication regimens have been described. There are little data reporting their efficacy or integration in routine clinical practice. The...