288 datasets found
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Federal
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Brain, Western Blot and ECLIA)
National Aeronautics and Space Administration —
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to... -
Federal
Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135
National Aeronautics and Space Administration —
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing... -
Federal
Proton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
National Aeronautics and Space Administration —
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological... -
Federal
Simulated Galactic Cosmic Ray Exposure Activates Dose-Dependent DNA Repair Response and Downregulates Glucosinolate Pathway in Arabidopsis Seedlings
National Aeronautics and Space Administration —
This study's objective was to develop an understanding of the biological effects of space radiation on plants with the goal of producing fresh food during long... -
Federal
Biological Research in Canisters-16 (BRIC-16): Transcriptomics, Glycomics, and Morphometric photography.
National Aeronautics and Space Administration —
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland transcriptomic, proteomic, and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
Transcriptomics analysis of etiolated Arabidopsis thaliana seedlings in response to microgravity
National Aeronautics and Space Administration —
Gene expression profile of two-week-old etiolated Arabidopsis seedlings under microgravity on board space flight BRIC16 were compared with ground grown control in... -
Federal
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus issensis, sp. nov., isolated from various quarters of the International Space Station
National Aeronautics and Space Administration —
As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected... -
Federal
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity
National Aeronautics and Space Administration —
Physical forces greatly influence the growth and function of an organism. Altered gravity can perturb normal development and induce corresponding changes in gene... -
Federal
Biomolecule Sequencer
National Aeronautics and Space Administration —
Technology demonstration of a nanopore sequencer operating aboard the ISS in comparison with the same sequencer on the ground. -
Federal
Biological and Metabolic Response in STS-135 Space-flown Mouse Skin
National Aeronautics and Space Administration —
Changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of... -
Federal
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice
National Aeronautics and Space Administration —
Spaceflight has been shown to suppress the adaptive immune response, altering the distribution and function of lymphocyte populations. B lymphocytes express highly... -
Federal
Comparison of the spaceflight transcriptome of four commonly used Arabidopsis thaliana ecotypes
National Aeronautics and Space Administration —
This experiment compared the spaceflight transcriptomes of four commonly used natural variants (ecotypes) of Arabidopsis thaliana using RNAseq. In nature, Arabidopsis... -
Federal
Immediate Transcriptional Changes in Response to High Dose Radiation Exposure
National Aeronautics and Space Administration —
One of the most likely risks astronauts on long duration space missions face is exposure to ionizing radiation associated with highly energetic and charged heavy... -
Federal
Microbial Observatory (ISS-MO): Draft Genome Sequence of two Aspergillus fumigatus Strains Isolated from the International Space Station
National Aeronautics and Space Administration —
Aspergillus fumigatus is a saprophytic, filamentous fungus that is ubiquitous outdoors (soil, decaying vegetation) and indoors (hospitals, simulated closed habitats,... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
Bacillus subtilis strains at low-pressure: 5 kPa versus 101 kPa growth
National Aeronautics and Space Administration —
Comparing the transcriptional responses of Bacillus subtilis strains WN624 and WN1106 at 5 kPa and 101 kPa. WN1106 is a 5 kPa-evolved strain with increased fitness... -
Federal
BRIC-23 GeneLab Process Verification Test: Bacillus subtilis transcriptomic, proteomic, and metabolomic data
National Aeronautics and Space Administration —
Microbes interact with humans in complex ways and understanding how they respond to the spaceflight environment is important to the success of future manned... -
Federal
Whole metagenome profiles of particulates collected from the International Space Station.
National Aeronautics and Space Administration —
The microbial composition of the International Space Station (ISS) environment is of critical interest due to potential impact of its constituents on human health and... -
Federal
Transient gene expression profile changes of confluent human fibroblast cells in spaceflight
National Aeronautics and Space Administration —
Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or...
288 datasets found