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    • Transient gene expression profile changes of confluent human fibroblast cells in spaceflight

    Metadata Updated: August 30, 2025

    Microgravity or an altered gravity environment from the static 1g has been shown to influence global gene expression patterns and protein levels in cultured cells or animals, but it is unclear how these changes in gene and protein expressions are related to each other or are related to other factors regulating such changes. Recent advancement in the field of molecular biology revealed that a different class of RNA, the small non-coding microRNA (miRNA), can have a broad effect on gene expression networks by mainly inhibiting the translational process. In this experiment conducted on the International Space Station, we propose to test the hypotheses that miRNA profiles will be altered in the space environment, and that cellular responses to DNA damage in space are different from those on the ground.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date April 11, 2025
    Metadata Updated Date August 30, 2025

    Metadata Source

    Harvested from NASA Data.json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date April 11, 2025
    Metadata Updated Date August 30, 2025
    Publisher Open Science Data Repository
    Maintainer
    Identifier 10.26030/rcyt-qp10
    Data Last Modified 2025-08-21
    Category Biological and Physical Sciences
    Public Access Level public
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id c2da0e9d-57a1-4d95-bdf5-241eb739b1ff
    Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
    Harvest Source Title NASA Data.json
    Homepage URL https://lsda.jsc.nasa.gov/scripts/mission/miss.aspx?mis_index=1372
    Program Code 026:000
    Source Datajson Identifier True
    Source Hash 97b69d75a6cb198ec74c75013c996400df7e9e66ea7a5ee988f0d9f4db97c832
    Source Schema Version 1.1

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