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Federal
Different effects of antisense RelA p65 and NF-κB1 p50 oligonucleotides on the nuclear factor-κB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells
U.S. Department of Health & Human Services —
Background Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α... -
Federal
Locations of several novel 2'-
U.S. Department of Health & Human Services —
Background Ribose 2'-O-methylation, the most common nucleotide modification in mammalian rRNA, is directed by the C/D box small nucleolar RNAs (snoRNAs). Thus far,... -
Federal
Interactions of pathogens and irritant chemicals in land-applied sewage sludges (biosolids)
U.S. Department of Health & Human Services —
Background Fertilisation of land with processed sewage sludges, which often contain low levels of pathogens, endotoxins, and trace amounts of industrial and household... -
Federal
Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA
U.S. Department of Health & Human Services —
Background The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited... -
Federal
Enhanced immunogenicity of a functional enzyme by T cell epitope modification
U.S. Department of Health & Human Services —
Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of... -
Federal
Pleasure in decision-making situations
U.S. Department of Health & Human Services —
Background This study explores the role of pleasure in decision making. Results In Experiment 1, 12 subjects were presented with a questionnaire containing 46 items... -
Federal
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
U.S. Department of Health & Human Services —
Background The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in... -
Federal
Pharmacological and ischemic preconditioning of the human myocardium: mitoK
U.S. Department of Health & Human Services —
Background These studies investigate the role of mitoKATP channels, protein kinase C (PKC) and Mitogen activated protein kinase (p38MAPK) on the cardioprotection of... -
Federal
Rational therapy of chronic venous insufficiency – chances and limits of the therapeutic use of horse-chestnut seeds extract
U.S. Department of Health & Human Services —
Background and methods We report two clinical studies, one already published, performed in patients with early and advanced chronic venous insufficiency (CVI). In... -
Federal
Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration
U.S. Department of Health & Human Services —
Background Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow... -
Federal
Hamster oocyte membrane potential and ion permeability vary with preantral cumulus cell attachment and developmental stage
U.S. Department of Health & Human Services —
Background In vitro maturation of mammalian oocytes is an area of great interest due to its potential application in the treatment of infertility. The morphological... -
Federal
CD26 immuno-expression and periodontal disease progression
U.S. Department of Health & Human Services —
Immunological mechanisms participate in the pathogenesis of human chronic inflammatory periodontal disease (CIPD). Human CD4+ lymphocytes express functionally... -
Federal
Phylogenetic relationships and taxonomic position of
U.S. Department of Health & Human Services —
Background Little is known about phytoplankton communities inhabiting low pH environments such as volcanic and geothermal sites or acidic waters. Only specialised... -
Federal
Survey of stress ulcer prophylaxis
U.S. Department of Health & Human Services —
Background: No surveys of stress ulcer prophylaxis prescribing in the USA have been conducted since 1995. Since that time, the most comprehensive meta-analysis and... -
Federal
Both subtelomeric regions are required and sufficient for specific DNA fragmentation during macronuclear development in
U.S. Department of Health & Human Services —
Background: Programmed DNA-reorganization and DNA-elimination events take place frequently during cellular differentiation. An extreme form of such processes,... -
Federal
Conservation and diversity of gene families explored using the CODEHOP strategy in higher plants
U.S. Department of Health & Human Services —
Background Availability of genomewide information on an increasing but still limited number of plants offers the possibility of identifying orthologues, or related... -
Federal
New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18-23, San Francisco
U.S. Department of Health & Human Services —
The 97th American Thoracic Society meeting proved to be an excellent meeting, providing a wealth of new information on inflammatory diseases of the airways. Once... -
Federal
Mobilization of seed storage lipid by Arabidopsis seedlings is retarded in the presence of exogenous sugars
U.S. Department of Health & Human Services —
Background Soluble sugar levels must be closely regulated in germinating seeds to ensure an adequate supply of energy and building materials for the developing... -
Federal
Microarray profile of differentially expressed genes in a monkey model of allergic asthma
U.S. Department of Health & Human Services —
Background Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed allergic reaction, including a pulmonary...