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Federal
(Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
U.S. Environmental Protection Agency —
To determine the best way to select predictive groups of genes, we used published microarray data from dose-response studies on six chemicals in rats exposed orally... -
Federal
High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling
U.S. Environmental Protection Agency —
Estimates of ionization equilibrium constants (i.e., pKa) were analyzed for 8,132 pharmaceuticals and 24,281 other compounds to which humans might be exposed in the... -
Federal
(ALTEX) Use of High-throughput in vitro toxicity screening data in cancer hazard evaluations by the IARC Monograph Working Groups
U.S. Environmental Protection Agency —
Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to... -
Federal
A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics
U.S. Environmental Protection Agency —
The U.S. Tox21 Federal collaboration, which currently quantifies the biological effects of nearly 10,000 chemicals via quantitative high-throughput screening(qHTS) in... -
Federal
Comprehensive analyses and prioritization of Tox21 10K chemicals affecting mitochondrial function by in-depth mechanistic studies
U.S. Environmental Protection Agency —
All data is generated outside of EPA by NCATS, NIH. EPA coauthors assisted with writing the manuscript. This dataset is not publicly accessible because: Data was not... -
Federal
(Toxicology) Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Applying a Quantitative High-throughput Screening Platform
U.S. Environmental Protection Agency —
The paper has data generated by NIH and the EPA coauthors provided input into the preparation of the manuscript. This dataset is not publicly accessible because: Data... -
Federal
NMReDATA, a standard to report the NMR assignment and parameters of organic compounds
U.S. Environmental Protection Agency —
Data S1. Example of NMReDATA.sdf file including NMReDATA for benzo[a]pyrene Data S2. Pure text translation of the NMReDATA.sdf of benzo[a]pyrene. This dataset is... -
Federal
Chemical Exposure Pathway Prediction for Screening and Priority-Setting
U.S. Environmental Protection Agency —
We created a consensus, meta-model using the Systematic Empirical Evaluation of Models framework in which the predictors of exposure were combined by pathway and... -
Federal
CES_EHP_Figure_2
U.S. Environmental Protection Agency —
The increasing number of chemicals for which SHEDS probabilistic exposure assessment has been performed over the years. This dataset is associated with the following... -
Federal
A harmonized chemical monitoring database for support of exposure assessments
U.S. Environmental Protection Agency —
Datasets for "A harmonized chemical monitoring database for support of exposure assessments". This dataset is associated with the following publication: Isaacs, K.,... -
Federal
High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity
U.S. Environmental Protection Agency —
Dataset consists of high throughput in vitro bioactivity data and exposure predictions from the U.S. EPA’s Toxicity and Exposure Forecaster (ToxCast and ExpoCast)... -
Federal
Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals
U.S. Environmental Protection Agency —
This investigation was broken down into three interrelated steps: data collection, model building, and model evaluation. R software (v. 3.5.1) with the httk package... -
Federal
Importance of predictor variables for models of chemical function
U.S. Environmental Protection Agency —
Importance of random forest predictors for all classification models of chemical function. This dataset is associated with the following publication: Isaacs , K., M.... -
Federal
CHEMICAL CHARACTERIZATION OF RECYCLED CONSUMER PRODUCTS USING SUSPECT SCREENING ANALYSIS
U.S. Environmental Protection Agency —
All data associated with Figures and Tables of manuscript "CHEMICAL CHARACTERIZATION OF RECYCLED CONSUMER PRODUCTS USING SUSPECT SCREENING ANALYSIS", Charles Lowe et... -
Federal
HTTK R Package v1.5 - Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability
U.S. Environmental Protection Agency —
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from... -
Federal
High-Throughput Dietary Exposure Predictions for Chemical Migrants from Food Contact Substances for Use in Chemical Prioritization
U.S. Environmental Protection Agency —
Under the ExpoCast program, United States Environmental Protection Agency (EPA) researchers have developed a high-throughput (HT) framework for estimating aggregate... -
Federal
In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning
U.S. Environmental Protection Agency —
QSAR Model Reporting Formats. Examples of R code: feature selection and regression analysis. Figure S1: Data distribution of logBCF, BP, MP and logVP. Figures S2–S5:... -
Federal
In vivo plasma concentration for lindane after 6 hour exposure in human skin
U.S. Environmental Protection Agency —
Dataset is a time course description of lindane disappearance in blood plasma after dermal exposure in human volunteers. This dataset is associated with the following... -
Federal
Non‐animal assessment of skin sensitization hazard: Is an integrated testing strategy needed, and if so what should be integrated?
U.S. Environmental Protection Agency —
Appendix Skin sensitization data and non‐animal test data for 271 chemicals. This dataset is associated with the following publication: Roberts, D., and G. Patlewicz.... -
Federal
RAIDAR-ICE manuscript data
U.S. Environmental Protection Agency —
Data from which figures and table in "A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources" were constructed....