HTTK R Package v1.5 - Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability

Metadata Updated: February 13, 2019

httk: High-Throughput Toxicokinetics

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

This dataset is associated with the following publication: Ring, C., R. Pearce, W. Setzer, B. Wetmore, and J. Wambaugh. (Environment International) Refining high-throughput prioritization of environmental chemicals to include inter-individual variability across subpopulations. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, USA, 106: 105-118, (2017).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

References

https://dx.doi.org/10.1016/j.envint.2017.06.004
http://www.sciencedirect.com/science/article/pii/S0160412017301204?via%3Dihub
http://ars.els-cdn.com/content/image/1-s2.0-S0160412017301204-mmc1.xlsx
http://ars.els-cdn.com/content/image/1-s2.0-S0160412017301204-mmc2.docx

Dates

Metadata Created Date October 3, 2017
Metadata Updated Date February 13, 2019

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date October 3, 2017
Metadata Updated Date February 13, 2019
Publisher U.S. EPA Office of Research and Development (ORD)
Unique Identifier https://doi.org/10.23719/1390268
Maintainer
John Wambaugh
Maintainer Email
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id af495e14-599a-44c2-952c-6febbf53f081
Harvest Source Id cf9b0004-f9fd-420e-bade-a86839e82acf
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Data Last Modified 2017-03-03
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://dx.doi.org/10.1016/j.envint.2017.06.004, http://www.sciencedirect.com/science/article/pii/S0160412017301204?via%3Dihub, http://ars.els-cdn.com/content/image/1-s2.0-S0160412017301204-mmc1.xlsx, http://ars.els-cdn.com/content/image/1-s2.0-S0160412017301204-mmc2.docx
Source Datajson Identifier True
Source Hash fd3ea53100a91c20754fb7a24f5a2248dd3cdb94
Source Schema Version 1.1

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