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Federal
Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines
U.S. Department of Health & Human Services —
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and... -
Federal
Ensuring competency in end-of-life care: controlling symptoms
U.S. Department of Health & Human Services —
Background Palliative medicine is assuming an increasingly important role in patient care. The Education for Physicians in End-of-life Care (EPEC) Project is an... -
Federal
Identifying older diabetic patients at risk of poor glycemic control
U.S. Department of Health & Human Services —
Background Optimal glycemic control prevents the onset of diabetes complications. Identifying diabetic patients at risk of poor glycemic control could help promoting... -
Federal
Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study
U.S. Department of Health & Human Services —
Background Celiac disease has a strong genetic association with HLA. However, this association only explains approximately half of the sibling risk for celiac... -
Federal
Individual variation evades the Prisoner's Dilemma
U.S. Department of Health & Human Services —
Background The Prisoner's Dilemma (PD) is a widely used paradigm to study cooperation in evolutionary biology, as well as in fields as diverse as moral philosophy,... -
Federal
A new era in hypertension research: discussing the findings of ALLHAT
U.S. Department of Health & Human Services —
The key question in hypertension research today is, "Does it matter how elevated blood pressure is lowered?" The Antihypertensive and Lipid-Lowering Treatment to... -
Federal
Comparison of complete nuclear receptor sets from the human,
U.S. Department of Health & Human Services —
Background The availability of complete genome sequences enables all the members of a gene family to be identified without limitations imposed by temporal, spatial or... -
Federal
Acetaminophen toxicity: suicidal vs accidental
U.S. Department of Health & Human Services —
Introduction Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit... -
Federal
Plasma colloid osmotic pressure in healthy infants
U.S. Department of Health & Human Services —
Background The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants... -
Federal
Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis
U.S. Department of Health & Human Services —
Background Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role... -
Federal
Research Article: Arthritis Research
U.S. Department of Health & Human Services —
This is a brief review of the third volume of the series edited by AN Theofilopoulos, "Current Directions in Autoimmunity". This hard-cover volume comprises 282... -
Federal
Open access to the scientific journal literature
U.S. Department of Health & Human Services —
None of the advantages of traditional scientific journals need be sacrificed in order to provide free online access to scientific journal articles. Objections that... -
Federal
Femoral vein size in newborns and infants: preliminary investigation
U.S. Department of Health & Human Services —
Background: The femoral vein is an important site for central venous access in newborns and infants. The objectives of this study are to determine whether age or... -
Federal
Role of arginine and its methylated derivatives in cancer biology and treatment
U.S. Department of Health & Human Services —
Both L-arginine supplementation and deprivation influence cell proliferation. The effect of high doses on tumours is determined by the optical configuration:... -
Federal
A Problem with the Individual Approach in the WHO Health Inequality Measurement
U.S. Department of Health & Human Services —
Background In the World Health Report 2000, the World Health Organization made the controversial choice to measure inequality across individuals rather than across... -
Federal
Role of bedside electroencephalography in the adult intensive care unit during therapeutic neuromuscular blockade
U.S. Department of Health & Human Services —
Background: Size, weight and technical difficulties limit the use of ponderous strip chart electroencephalographs (EEGs) for real time evaluation of brain wave... -
Federal
Use of a rapid arterial blood gas analyzer to estimate blood hemoglobin concentration among critically ill adults
U.S. Department of Health & Human Services —
Objective To evaluate whether measurement of the hemoglobin (Hb) concentration with a blood gas analyzer approximates that determined by a conventional coulter... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Clinical experience
U.S. Department of Health & Human Services —
In the past 5 years, around 350 patients have received haematopoietic stem cell (HSC) transplantation for an autoimmune disease, with 275 of these registered in an... -
Federal
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol
U.S. Department of Health & Human Services —
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been... -
Federal
Aged garlic extract therapy for sickle cell anemia patients
U.S. Department of Health & Human Services —
Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a...