48 datasets found
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Federal
Microarray Profile of Gene Expression during Osteoclast Differentiation in Modeled Microgravity
National Aeronautics and Space Administration —
Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA... -
Federal
Low dose ionizing radiation treated lymphoblastoid cells
National Aeronautics and Space Administration —
Irradiated cell lines exposed to 1-10 Gy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 Gy RNA is isolated and labeled using a T7... -
Federal
Comparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions
National Aeronautics and Space Administration —
The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human... -
Federal
Identifying radiation exposure biomarkers from mouse blood transcriptome
National Aeronautics and Space Administration —
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological... -
Federal
Microarray Profile of Gene Expression during Osteoclast Differentiation in Modeled Microgravity
National Aeronautics and Space Administration —
Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA... -
Federal
T Cell Activation in Microgravity Compared to 1g (Earth s) Gravity
National Aeronautics and Space Administration —
This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (mg). Immunosuppression during... -
Federal
Gene responses in mouse brain to long-term exposure to microgravity
National Aeronautics and Space Administration —
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed... -
Federal
Genechip analysis of bone marrow osteoprogenitors exposed to microgravity
National Aeronautics and Space Administration —
In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on... -
Federal
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure
National Aeronautics and Space Administration —
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling.... -
Federal
Microgravity effect on C. elegans N2/VC (CERISE 8days)
National Aeronautics and Space Administration —
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 8 days in the Japanese... -
Federal
Expression data from SPHINX (SPaceflight of Huvec: an INtegrated eXperiment)
National Aeronautics and Space Administration —
Changes in the physical environment modulate cell responses and may lead to the impairment or even failure of tissue function as a result of mechanotransduction... -
Federal
Salmonella Typhimurium transcription profiles in space flight
National Aeronautics and Space Administration —
Salmonella transcription profiles were obtained from samples flown on space shuttle mission STS-115 and compared to profiles from Salmonella grown under identical... -
Federal
Low dose ionizing radiation treated lymphoblastoid cells
National Aeronautics and Space Administration —
Irradiated cell lines exposed to 1-10 cGy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 cGy RNA is isolated and labeled using a T7... -
Federal
Genechip analysis of bone marrow osteoprogenitors exposed to microgravity
National Aeronautics and Space Administration —
In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on... -
Federal
Gene expression profiling of C. elegans under various thermal conditions
National Aeronautics and Space Administration —
To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to... -
Federal
Expression data from SPHINX (SPaceflight of Huvec: an INtegrated eXperiment)
National Aeronautics and Space Administration —
Changes in the physical environment modulate cell responses and may lead to the impairment or even failure of tissue function as a result of mechanotransduction... -
Federal
IMR90 bystander experiment 0.5 Gy alpha particle
National Aeronautics and Space Administration —
The existence of a radiation bystander effect in which non-irradiated cells respond to signals from irradiated cells is well established. It raises concerns for the... -
Federal
DNA copy number analysis from mice with radiation-induced acute myeloid leukemia
National Aeronautics and Space Administration —
Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using... -
Federal
An environment with strong gravitational and magnetic field alterations synergizes to promote variations in Arabidopsis thaliana callus global transcriptional state
National Aeronautics and Space Administration —
Using diamagnetic levitation we have exposed A. thaliana in vitro callus cultures to five environments with different levels of effective gravity (from levitation... -
Federal
Human skin fibroblast mitochondrial depletion 0.5 Gy alpha-particle
National Aeronautics and Space Administration —
Mitochondrial DNA-depleted human skin fibroblasts (HSF rho0) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of...
48 datasets found