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Federal
Experience collecting interim data on mortality: an example from the RALES study
U.S. Department of Health & Human Services —
Introduction The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary... -
Federal
Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?
U.S. Department of Health & Human Services —
Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials... -
Federal
Mutant loxP vectors for selectable marker recycle and conditional knock-outs
U.S. Department of Health & Human Services —
Background Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40... -
Federal
Research Article: Journal of Biomedicine and Biotechnology
U.S. Department of Health & Human Services —
An intense suppression of T cell proliferation to mitogens and to antigens is observed in a large number of parasitic infections. The impairment of T cell... -
Federal
Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children
U.S. Department of Health & Human Services —
Background It is known that proinflammatory and anti-inflammatory cytokines are released during and after cardiopulmonary bypass (CPB) in infants and children. Sex... -
Federal
Ecdysteroids and oocyte development in the black fly
U.S. Department of Health & Human Services —
Background Oocyte development was studied in the autogenous black fly, Simulium vittatum (Diptera, Nematocera), a vector of Onchocerca volvulus, the causative agent... -
Federal
Managing death in the intensive care unit: bringing back the humanity
U.S. Department of Health & Human Services —
Managing death in the intensive care unit: bringing back the humanity -
Federal
Comparison of complete nuclear receptor sets from the human,
U.S. Department of Health & Human Services —
Background The availability of complete genome sequences enables all the members of a gene family to be identified without limitations imposed by temporal, spatial or... -
Federal
Assessing the knowledge of bronchial asthma among primary health care physicians in Crete: A pre- and post-test following an educational course
U.S. Department of Health & Human Services —
Aim To assess the level of knowledge for bronchial asthma of the primary healthcare physicians serving a rural population on the island of Crete, both before and... -
Federal
Mini-laparoscopic versus laparoscopic approach to appendectomy
U.S. Department of Health & Human Services —
Background The purpose of this clinical study is to evaluate the feasibility of using 2-mm laparoscopic instruments to perform an appendectomy in patients with... -
Federal
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
U.S. Department of Health & Human Services —
Background Mild cognitive impairment (MCI) was recently described as a heterogeneous group with a variety of clinical outcomes and high risk to develop Alzheimer's... -
Federal
Assessment of the infectious diseases surveillance system of the Republic of Armenia: an example of surveillance in the Republics of the former Soviet Union
U.S. Department of Health & Human Services —
Background Before 1991, the infectious diseases surveillance systems (IDSS) of the former Soviet Union (FSU) were centrally planned in Moscow. The dissolution of the... -
Federal
Combating Kinetoplastid diseases
U.S. Department of Health & Human Services —
Today's Kinetoplastida form a diverse order of flagellated protozoans that have evolved from an ancient lineage, rooted near the base of the eukaryotic tree. The... -
Federal
Taking stock of gene therapy for cystic fibrosis
U.S. Department of Health & Human Services —
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal... -
Federal
Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials
U.S. Department of Health & Human Services —
Background Gastric ulcers are a frequent problem in the United States. Proton pump inhibitors have been shown to increase healing rates and improve clinical symptoms.... -
Federal
Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patients
U.S. Department of Health & Human Services —
Background The autoimmune thyroid diseases (AITDs), such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex... -
Federal
Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis
U.S. Department of Health & Human Services —
Background Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role... -
Federal
Comparison of the sensitivity of a 24 h-shell vial assay, and conventional tube culture, in the isolation of Herpes simplex virus – 1 from corneal scrapings
U.S. Department of Health & Human Services —
Background Herpes simplex keratitis is a sight threatening ocular infection. A rapid and specific diagnosis is essential for the institution of specific antiviral... -
Federal
Stage-specific changes in fetal thymocyte proliferation during the CD4
U.S. Department of Health & Human Services —
Background The function of the thymic microenvironment is to promote thymocyte maturation, in part via regulation of thymocyte proliferation and cell death. Defects... -
Federal
Oriented antibody immobilization to polystyrene macrocarriers for immunoassay modified with hydrazide derivatives of poly(meth)acrylic acid
U.S. Department of Health & Human Services —
Background Hydrophobic polystyrene is the most common material for solid phase immunoassay. Proteins are immobilized on polystyrene by passive adsorption, which often...