288 datasets found
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Federal
Heart Flies - effect of microgravity on heart function in Drosophila
National Aeronautics and Space Administration —
Canton S laboratory wildtype lines (Bloomington Stock Center) and a K+ channel mutant seizure (seizurets1, a gift from Dr. Barry Ganetsky, published in Titus et al.,... -
Federal
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures (Flow Cytometry, Blood)
National Aeronautics and Space Administration —
In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle... -
Federal
Proteomics and Transcriptomics analysis of Arabidopsis Seedlings in Microgravity
National Aeronautics and Space Administration —
On Earth plants are constantly exposed to a gravitational field of 1G. Gravity affects a plant in every step of its development. Germinating seedlings orient their... -
Federal
Draft Genome Sequences of novel Agrobacterium genomospecies 3 Associated from the International Space Station
National Aeronautics and Space Administration —
The whole-genome sequences (WGS) of three pathogenic bacterial strains collected from the International Space Station (ISS) were generated and identified as being... -
Federal
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight.
National Aeronautics and Space Administration —
Microphysiological systems provide the opportunity to model accelerated changes at the human tissue level in the extreme space environment. Spaceflight-induced muscle... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse quadriceps muscle transcriptomic, proteomic, and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
Altered Quorum Sensing and Physiology of Staphylococcus aureus During Spaceflight Detected by Multi-omics Data Analysis (BRIC-23: Secretomics)
National Aeronautics and Space Administration —
Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor for opportunistic infections. Because of the potential threat of S. aureus to... -
Federal
Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight from RR-1 and RR-9 (calcium uptake and Western blot in soleus and tibialis anterior)
National Aeronautics and Space Administration —
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a... -
Federal
Transcription profiling of rat response to changes in developmental stage - 3 types of tissue, 3 gravity conditions, 2 developmental conditions
National Aeronautics and Space Administration —
Transcriptional crosstalk between mammary gland, liver and adipose tissue Experiment Overall Design: Pregnant and Lactating rats exposed to 3 gravity conditions -
Federal
Arg1 functions in the physiological adaptation of undifferentiated plant cells to spaceflight
National Aeronautics and Space Administration —
In this study transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity-1 (Arg1), a gene known to affect... -
Federal
Specific Host Metabolite and Gut Microbiome Alterations Are Associated with Bone-loss During Spaceflight
National Aeronautics and Space Administration —
Understanding the axis of the human microbiome and physiological homeostasis is an essential task in managing deep-space travel associated health risks. The NASA led... -
Federal
Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model
National Aeronautics and Space Administration —
Physical forces associated with spaceflight and spaceflight analogue culture regulate a wide range of physiological responses by both bacterial and mammalian cells... -
Federal
Single cell transcriptional profiling of spleens from mice flown on Rodent Research Reference Mission-2 (RRRM-2)
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Metagenomic analysis of feces from mice flown on the RR-6 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-6 (RR-6) study was to evaluate muscle atrophy in mice during spaceflight and to test the efficacy of a novel therapeutic to... -
Federal
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
National Aeronautics and Space Administration —
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in... -
Federal
Transcriptional analysis of femoral skin from mice flown on the RR-5 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-5 (RR-5) study was to evaluate bone loss in mice during spaceflight and to determine if treatment with a modified version of NEL-... -
Federal
Response of human lymphoblastoid cells to HZE (iron ions) or gamma-rays
National Aeronautics and Space Administration —
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiated cells with cells exposed 24 hours previously to 1.67 Gy HZE (1 GeV/amu iron ions... -
Federal
Bulk RNA sequencing and spatially resolved transcriptional profiling of cerebellums from mice flown on the RRRM-2 mission
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Transcription profiling of S. cerevisiae cultures grown under low shear-modeled microgravity
National Aeronautics and Space Administration —
The goal of this study was to assess whether low shear-modeled microgravity (LSMMG) affects yeast genomic expression patterns using the powerful tool of whole genome...
288 datasets found