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Federal
Gravitational signature of synchronized cell cultures in particular cell cycle stages recent views
National Aeronautics and Space Administration —
Cell cycle and cell proliferation are decoupled under altered gravity conditions. We have previously shown that semisolid cell cultures of Arabidopsis suffer overall... -
Federal
Rodent Research-1 (RR1) National Lab Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data recent views
National Aeronautics and Space Administration —
The Rodent Reasearch-1 National Lab (RR-1 CASIS) experiment was performed to study the effect of microgravity on muscle wasting. RNA DNA and protein were purified... -
Federal
Rodent Research-3-CASIS: Mouse liver transcriptomic proteomic and epigenomic data recent views
National Aeronautics and Space Administration —
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Federal
Proton irradiation augments the reduction in tumor progression observed with advanced age recent views
National Aeronautics and Space Administration —
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have... -
Federal
Radiation responses in peripheral white blood cells of smokers and non-smokers recent views
National Aeronautics and Space Administration —
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not... -
Federal
Root transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate recent views
National Aeronautics and Space Administration —
Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars.... -
Federal
STS-135 Cerebellum Transcriptomics recent views
National Aeronautics and Space Administration —
Mice were flown onboard STS-135 and returned to Earth for analysis. Cerebellums were collected within 3-4 hours of landing and snap frozen in liquid nitrogen. Samples... -
Federal
A whole-genome microarray study of Arabidopsis thaliana cell cultures exposed to microgravity for 5 days on board of Shenzhou 8 recent views
National Aeronautics and Space Administration —
Arabidopsis thaliana wild type cell cultures were exposed to a 5-day space flight onboard of Shenzhou 8 to identify microgravity and space effect related gene... -
Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight) recent views
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Microgravity effect on C. elegans N2/VC (CERISE 8days) recent views
National Aeronautics and Space Administration —
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 8 days in the Japanese... -
Federal
Environmental and facility conditions promote singular gravity responses of transcriptome during Drosophila metamorphosis recent views
National Aeronautics and Space Administration —
Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene... -
Federal
Transcription profiling of Drosophila exposed to a levitation magnet for different lengths of time recent views
National Aeronautics and Space Administration —
Drosophila samples were exposed to the levitation magnet inside a 25mm diameter tubes with 3 ml of yeast-based Drosophila food in the bottom and a chamber of only 5... -
Federal
Gene expression response to simulated gravity and hypergravity in human T cells recent views
National Aeronautics and Space Administration —
We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared... -
Federal
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes recent views
National Aeronautics and Space Administration —
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene... -
Federal
Microarray Analysis of Space-flown Murine Thymus Tissue recent views
National Aeronautics and Space Administration —
Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to... -
Federal
Response of human lymphoblastoid cells to HZE (iron ions) or gamma-rays recent views
National Aeronautics and Space Administration —
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiated cells with cells exposed 24 hours previously to 1.67 Gy HZE (1 GeV/amu iron ions... -
Federal
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity recent views
National Aeronautics and Space Administration —
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We... -
Federal
Identifying radiation exposure biomarkers from mouse blood transcriptome recent views
National Aeronautics and Space Administration —
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological... -
Federal
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight [plasma proteomics] recent views
National Aeronautics and Space Administration —
Among the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass. One signaling pathway that plays an important role in... -
Federal
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station recent views
National Aeronautics and Space Administration —
In recent times long-term stay has become a common occurrence in the International Space Station (ISS). However adaptation to the space environment can sometimes pose...