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Federal
Signal analysis of behavioral and molecular cycles
U.S. Department of Health & Human Services —
Background Circadian clocks are biological oscillators that regulate molecular, physiological, and behavioral rhythms in a wide variety of organisms. While behavioral... -
Federal
Representation of women's health in general medical versus women's health specialty journals: a content analysis
U.S. Department of Health & Human Services —
Background Women's health, traditionally defined, emphasises reproductive and maternal conditions without consideration of social contexts. Advocates urge a broader... -
Federal
Use of antihypertensive medications in pregnancy and the risk of adverse perinatal outcomes: McMaster Outcome Study of Hypertension In Pregnancy 2 (
U.S. Department of Health & Human Services —
Background Uncertainty remains about the potential harmful effects of antihypertensive therapy on the developing fetus, especially for beta-blockers (βb). Methods We... -
Federal
Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture
U.S. Department of Health & Human Services —
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical... -
Federal
p53 in rheumatoid arthritis: friend or foe?
U.S. Department of Health & Human Services —
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid... -
Federal
How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
U.S. Department of Health & Human Services —
Background It has been recognized that replicates of arrays (or spots) may be necessary for reliably detecting differentially expressed genes in microarray... -
Federal
Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to evidence?
U.S. Department of Health & Human Services —
Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been... -
Federal
Osmotic stress-dependent serine phosphorylation of the histidine kinase homologue DokA
U.S. Department of Health & Human Services —
Background Two-component systems consisting of histidine kinases and their corresponding receivers are widespread in bacterial signal transduction. In the past few... -
Federal
Withdrawal of cerivastatin from the world market
U.S. Department of Health & Human Services —
Cerivastatin was recently withdrawn from the market because of 52 deaths attributed to drug-related rhabdomyolysis that lead to kidney failure. The risk was found to... -
Federal
Organisational development in general practice: lessons from practice and professional development plans (PPDPs)
U.S. Department of Health & Human Services —
Background Improving the quality and effectiveness of clinical practice is becoming a key task within all health services. Primary medical care, as organised in the... -
Federal
Understanding childhood asthma in focus groups: perspectives from mothers of different ethnic backgrounds
U.S. Department of Health & Human Services —
Background Diagnosing childhood asthma is dependent upon parental symptom reporting but there are problems in the use of words and terms. The purpose of this study... -
Federal
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
U.S. Department of Health & Human Services —
Background Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked... -
Federal
The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials
U.S. Department of Health & Human Services —
To comprehend the results of a randomized controlled trial (RCT), readers must understand its design, conduct, analysis and interpretation. That goal can only be... -
Federal
Quality end-of-life care: A global perspective
U.S. Department of Health & Human Services —
Background Quality end-of-life care has emerged as an important concept in industrialized countries. Discussion We argue quality end-of-life care should be seen as a... -
Federal
A genomic timescale for the origin of eukaryotes
U.S. Department of Health & Human Services —
Background Genomic sequence analyses have shown that horizontal gene transfer occurred during the origin of eukaryotes as a consequence of symbiosis. However, details... -
Federal
Korean women: breast cancer knowledge, attitudes and behaviors
U.S. Department of Health & Human Services —
Introduction Clustered within the nomenclature of Asian American are numerous subgroups, each with their own ethnic heritage, cultural, and linguistic... -
Federal
The burden of pediatric HIV/AIDS in Constanta, Romania: a cross-sectional study
U.S. Department of Health & Human Services —
Background By 1990, 94 percent of the acquired immunodeficiency syndrome (AIDS) cases in Romania were in children less than 13 years of age. The majority of the cases... -
Federal
What kind of evidence is it that Evidence-Based Medicine advocates want health care providers and consumers to pay attention to?
U.S. Department of Health & Human Services —
Background In 1992, Evidence-Based Medicine advocates proclaimed a "new paradigm", in which evidence from health care research is the best basis for decisions for... -
Federal
Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIV
U.S. Department of Health & Human Services —
Background HIV-I can be transmitted by intravenous inoculation of contaminated blood or blood product or sexually through mucosal surfaces. Here we performed a pilot... -
Federal
Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol
U.S. Department of Health & Human Services —
Background Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III...