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Federal
Computational Model of Secondary Palate Fusion and Disruption ChemResTox Data
U.S. Environmental Protection Agency —
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from... -
Federal
Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature
U.S. Environmental Protection Agency —
A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database... -
Federal
Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines
U.S. Environmental Protection Agency —
Biomarker Image Cytometry. The cell-level frequency of NK2 Homeobox 1 (NKX2-1), Keratin 7 (KRT7), and Thyroglobulin (TG) protein staining were quantitatively... -
Federal
TZurlinden_pluripotent human (H9) embryonic stem cell
U.S. Environmental Protection Agency —
The data presented here support the application of the Stemina devTOXqP platform for predictive toxicology and further demonstrate its value in ToxCast as a novel... -
Federal
Computational Modeling and Simulation of Genital Tubercle Development
U.S. Environmental Protection Agency —
Hypospadias is a developmental defect of urethral tube closure that has a complex etiology involving genetic and environmental factors, including anti-androgenic and... -
Federal
Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure.
U.S. Environmental Protection Agency —
Background: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological... -
Federal
Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes
U.S. Environmental Protection Agency —
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses... -
Federal
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening
U.S. Environmental Protection Agency —
The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively... -
Federal
A cross-platform approach to characterize and screen potential neurovascular unit toxicants
U.S. Environmental Protection Agency —
Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and... -
Federal
Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes
U.S. Environmental Protection Agency —
Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and... -
Federal
Saili_AOP43_Systems Modeling of Developmental Vascular Toxicity
U.S. Environmental Protection Agency —
The AOP concept was used to translate ToxCast high-throughput screening data into a ToxPi matrix of 1058 chemicals x 24 features ordered by predicted potential to... -
Federal
K_Saili_Molecular characterization of a toxicological tipping point during human stem cell differentiation
U.S. Environmental Protection Agency —
We differentiated human induced pluripotent stem cells (hiPSCs) to embryonic endoderm and sought to identify a tipping point at which the developing system did not...