Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes." Using in vitro data to estimate point of departure (POD) values is an important component of new approach method (NAM)-based chemical risk assessments. In this case study we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI) and in vitro to in vivo extrapolation (IVIVE).
This dataset is associated with the following publication:
Shah, I., T. Antonijevic, B. Chambers, J. Harrill, and R. Thomas. Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(2): 285-301, (2021).
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Thomas Knudsen", "hasEmail": "mailto:knudsen.thomas@epa.gov" } |
| description | This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes." Using in vitro data to estimate point of departure (POD) values is an important component of new approach method (NAM)-based chemical risk assessments. In this case study we evaluated a NAM for hepatotoxicity based on rat primary hepatocytes, high-content imaging (HCI) and in vitro to in vivo extrapolation (IVIVE). This dataset is associated with the following publication: Shah, I., T. Antonijevic, B. Chambers, J. Harrill, and R. Thomas. Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(2): 285-301, (2021). |
| distribution |
[ { "title": "https://github.com/i-shah/heprn-hci-nam", "accessURL": "https://github.com/i-shah/heprn-hci-nam" } ] |
| identifier | https://doi.org/10.23719/1520925 |
| keyword |
[ "hepatotoxicity", "high-content imaging", "new approach methodologies", "pbtk", "point of departure", "repeat dose toxicity", "tipping points", "virtual embryo", "virtual liver", "virtual tissues" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2020-09-09 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1093/toxsci/kfab091" ] |
| rights |
null
|
| title | Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes |
