4 datasets found
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Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this... -
Federal
Prominent medical journals often provide insufficient information to assess the validity of studies with negative results
U.S. Department of Health & Human Services —
Background Physicians reading the medical literature attempt to determine whether research studies are valid. However, articles with negative results may not provide... -
Federal
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
U.S. Department of Health & Human Services —
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power,... -
Federal
How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
U.S. Department of Health & Human Services —
Background It has been recognized that replicates of arrays (or spots) may be necessary for reliably detecting differentially expressed genes in microarray...
4 datasets found