97 datasets found
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Federal
Expression profiling of
U.S. Department of Health & Human Services —
A combination of linear RNA amplification and DNA microarray hybridization has allowed the determination of expression profiles of individual imaginal discs and... -
Federal
Analysis of a human brain transcriptome map
U.S. Department of Health & Human Services —
Background Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our... -
Federal
The dominance of the population by a selected few: power-law behaviour applies to a wide variety of genomic properties
U.S. Department of Health & Human Services —
The sequencing of genomes provides us with an inventory of the 'molecular parts' in nature, such as protein families and folds, and their functions in living... -
Federal
Gene expression neighborhoods
U.S. Department of Health & Human Services —
The finding that neighboring eukaryotic genes are often expressed in similar patterns suggests the involvement of chromatin domains in the control of genes within a... -
Federal
Improved analytical methods for microarray-based genome-composition analysis
U.S. Department of Health & Human Services —
Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that... -
Federal
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application
U.S. Department of Health & Human Services —
Background A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic... -
Federal
Gene-expression profile comparisons distinguish seven organs of maize
U.S. Department of Health & Human Services —
Relative mRNA levels from maize organs have been quantified by hybridization to maize arrays fabricated with 5,376 unique expressed sequence tag clones. mRNAs from... -
Federal
TheTnfrh1(Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
U.S. Department of Health & Human Services —
TheTnfrh1gene (gene symbolTnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest... -
Federal
Genomic approaches to research in pulmonary hypertension
U.S. Department of Health & Human Services —
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic... -
Federal
Transcriptional territories in the genome
U.S. Department of Health & Human Services —
An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not... -
Federal
The cloning, genomic organization and tissue expression profile of the human DLG5 gene
U.S. Department of Health & Human Services —
Background Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is... -
Federal
Vector algebra in the analysis of genome-wide expression data
U.S. Department of Health & Human Services —
Background Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these... -
Federal
Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes
U.S. Department of Health & Human Services —
Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three... -
Federal
Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma
U.S. Department of Health & Human Services —
Background Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has... -
Federal
Glucocorticoids: do we know how they work?
U.S. Department of Health & Human Services —
It is not known to what extent glucocorticoid hormones cause their anti-inflammatory actions and their undesirable side effects by the same or different molecular... -
Federal
Genomic organization and alternative splicing of the human and mouse RPTPρ genes
U.S. Department of Health & Human Services —
Background Receptor protein tyrosine phosphatase rho (RPTPρ, gene symbol PTPRT) is a member of the type IIB RPTP family. These transmembrane molecules have been... -
Federal
A transcriptional response to Wnt protein in human embryonic carcinoma cells
U.S. Department of Health & Human Services —
Background Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known... -
Federal
Evidence for large domains of similarly expressed genes in the
U.S. Department of Health & Human Services —
Background Transcriptional regulation in eukaryotes generally operates at the level of individual genes. Regulation of sets of adjacent genes by mechanisms operating... -
Federal
Profound effect of normalization on detection of differentially expressed genes in oligonucleotide microarray data analysis
U.S. Department of Health & Human Services —
A number of procedures for normalization and detection of differentially expressed genes have been proposed. Four different normalization methods and all possible... -
Federal
New feature subset selection procedures for classification of expression profiles
U.S. Department of Health & Human Services —
Background Methods for extracting useful information from the datasets produced by microarray experiments are at present of much interest. Here we present new methods...
97 datasets found