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Federal
A family of putative K
U.S. Department of Health & Human Services —
Background Prior to this report, members of the inward rectifier family, or Kir, have been found only in eukaryotes. Like most K+ channels, the pore-forming part of... -
Federal
Noncoding RNA gene detection using comparative sequence analysis
U.S. Department of Health & Human Services —
Background Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Noncoding RNA gene sequences do not have strong... -
Federal
A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure
U.S. Department of Health & Human Services —
Background: The aim of this study was to test the hypothesis that a new mode of ventilation (pressure-regulated volume control; PRVC) is associated with improvements... -
Federal
Which treatment for low back pain? A factorial randomised controlled trial comparing intravenous analgesics with oral analgesics in the emergency department and a centrally acting muscle relaxant with placebo over three days [ISRCTN09719705]
U.S. Department of Health & Human Services —
Background About two thirds of adults suffer from backpain at some time during their life. In the emergency room many patients with acute back pain are treated with... -
Federal
Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific
U.S. Department of Health & Human Services —
Background Previous studies have revealed that tumour necrosis factor (TNF)-α is upregulated in fibrosing alveolitis (FA) in humans. The aim of this study was to... -
Federal
Echocardiography: a fundamental part of the intensive care curriculum
U.S. Department of Health & Human Services —
Echocardiography: a fundamental part of the intensive care curriculum -
Federal
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo
U.S. Department of Health & Human Services —
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive... -
Federal
The role of chlorophyll
U.S. Department of Health & Human Services —
Background The physico-chemical properties of chlorophylls b and c have been known for decades. Yet the mechanisms by which these secondary chlorophylls support... -
Federal
Use of the direct puncture technique in management of capillaro-venous malformations: case report
U.S. Department of Health & Human Services —
Background Preoperative devascularization of the capillaro-venous malformations located in the aero-digestive tract is important for surgeons, to minimize blood loss... -
Federal
Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598]
U.S. Department of Health & Human Services —
Background Hydroxymethylglutaryl coenzyme A reductase inhibitors increase new bone formation in vitro and in rodents. Results of epidemiologic analyses evaluating the... -
Federal
Intraocular pressure in genetically distinct mice: an update and strain survey: Correction
U.S. Department of Health & Human Services —
Intraocular pressure in genetically distinct mice: an update and strain survey: Correction -
Federal
"In-gel" purified ditags direct synthesis of highly efficient SAGE Libraries
U.S. Department of Health & Human Services —
Background SAGE (serial analysis of gene expression) is a recently developed technique for systematic analysis of eukaryotic transcriptomes. The most critical step in... -
Federal
Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?
U.S. Department of Health & Human Services —
The lowering of high blood pressure is supposed to protect target organs from hypertensive damage. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart... -
Federal
The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue
U.S. Department of Health & Human Services —
Background During wound repair, fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin, cellular fibronectin and collagen... -
Federal
Pro/con clinical debate: do colloids have advantages over crystalloids in paediatric sepsis?
U.S. Department of Health & Human Services —
Despite decades of resuscitating patients with intravenous fluids in intensive care units, it is somewhat surprising that very little consensus exists regarding the... -
Federal
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
U.S. Department of Health & Human Services —
Background Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly... -
Federal
Chemokines and their role in airway hyper-reactivity
U.S. Department of Health & Human Services —
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and... -
Federal
FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)
U.S. Department of Health & Human Services —
We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice... -
Federal
The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates
U.S. Department of Health & Human Services —
Background: Uracil DNA glycosylases (UDGs) are major repair enzymes that protect DNA from mutational damage caused by uracil incorporated as a result of a polymerase... -
Federal
Prediction models in the design of neural network based ECG classifiers: A neural network and genetic programming approach
U.S. Department of Health & Human Services —
Background Classification of the electrocardiogram using Neural Networks has become a widely used method in recent years. The efficiency of these classifiers depends...